Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes

当血糖水平高时，胰岛素向脂肪和肌肉细胞发出信号，将葡萄糖从血液中移除。葡萄糖的摄取依赖于膜融合事件，该事件将特定的葡萄糖转运蛋白传递到细胞表面以响应胰岛素信号。这一过程在II型糖尿病中受到影响。我们的研究将描述这些膜融合事件的调节特征，对于理解胰岛素信号在健康和疾病中是如何传递的非常重要。

When blood glucose levels are high, insulin signals to fat and muscle cells to remove glucose from the blood. The uptake of glucose relies on membrane fusion events that deliver a specific glucose transporter protein to the cell surface in response to insulin signals. This process is affected in Type II diabetes. Our research will characterise the regulation of these membrane fusion events and will be important for understanding how insulin signals are communicated in health and disease.