UCLA OLDER AMERICANS INDEPENDENCE CENTER

描述(由申请人提供)：加州大学洛杉矶分校克劳德·D·佩珀老年美国人独立中心(UCLA OAIC)成立于1991年，寻求第三次更新，以继续其扩大科学知识的使命，这将导致更好地保持或恢复独立。在这次更新中，我们将把我们的努力集中在“发展干预措施以保持独立性和理解成功干预措施的机制”这一主题上，这是对该中心先前研究的扩展。因此，重点将放在在基础生物医学科学和临床科学之间建立桥梁的研究上。在加州大学洛杉矶分校的OAIC范式中，基础生物医学研究为临床研究提供信息，临床研究为基础生物医学研究提供信息。因此，加州大学洛杉矶分校OAIC将支持在两个方向上将这两种类型的研究联系起来的研究，方法是1)检查成功的临床干预背后的机制，2)开发将导致临床干预的新的基础科学方法。该中心将通过4个研究核心(招聘、研究运作、分析和成本效益、炎症生物学)、试点和探索性研究(P/EC)核心和研究职业发展核心(RCDC)促进科学发现。研究中心将为外部项目(例如R01)和OAIC内部活动(例如飞行员和职业发展奖获得者)提供4个级别的支持(咨询、短期、持续和新项目伙伴关系)。加州大学洛杉矶分校OAIC将通过实现6个具体目标来实现其目标：1)为中心主题和相关研究的老年病学和老龄化研究提供智力领导和创新2)刺激基础研究和临床研究之间的翻译联系，重点是炎症3)促进和开发新的多学科研究4)刺激新兴技术的结合5)作为其他机构的建议和合作的来源6)为未来的研究领导者提供职业发展。

DESCRIPTION (provided by applicant): Established in 1991, the UCLA Claude D. Pepper Older Americans Independence Center (UCLA OAIC) seeks a third renewal to continue its mission of expanding the scientific knowledge that will lead to better ways to maintain or restore independence. In this renewal, we will focus our efforts on the theme, "Developing Interventions to Maintain Independence and Understanding Mechanisms of Successful Interventions," which extends the Center's prior research. Thus, the emphasis will be on research that builds bridges between basic biomedical science and clinical science. In the UCLA OAIC paradigm, basic biomedical research informs clinical research and clinical research informs basic biomedical research. Accordingly, the UCLA OAIC will support research that links these two types of research in both directions by 1) examining mechanisms underlying successful clinical interventions and 2) developing new basic science approaches that will lead to clinical interventions. The Center will stimulate scientific discovery through 4 Research Cores (Recruitment, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies (P/EC) Core, and Research Career Development Core (RCDC). Research Cores will provide 4 levels of support (consultation, short-term, ongoing, and partnership on new projects) for external projects (e.g., R01s) and internal OAIC activities (e.g., pilots and Career Development Awardees). The UCLA OAIC will accomplish its goals by accomplishing 6 Specific Aims: 1) To provide intellectual leadership and innovation for geriatrics and aging research on the Center's theme and related research 2) To stimulate translational links between basic and clinical research, with an emphasis on inflammation 3) To facilitate and develop novel multidisciplinary research 4) To stimulate incorporation of emerging technologies 5) To serve as source of advice and collaboration to other institutions 6) To provide career development of future research leaders.