WEIGHT LOSS AND ASTHMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 流行病学和基础科学研究有非常有力的证据表明，肥胖可能会影响哮喘。这对美国民众的健康有着非常重要的影响。了解体重减轻引起的生理和炎症变化将有助于我们理解肥胖与哮喘之间的关系。我们建议对一组接受胃旁路手术治疗病态肥胖的哮喘患者进行前瞻性试验。我们将测量体重减轻引起的生理和炎症变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is very strong evidence from epidemiological and basic science studies to suggest that obesity may affect asthma. This has very important implications for the health of the US population. Understanding the physiological and inflammatory changes induced by weight loss would make an important contribution to our understanding of the relationship between obesity and asthma. We propose a prospective trial of a cohort of asthmatics undergoing gastric-bypass surgery for morbid obesity. We will measure physiological and inflammatory changes induced by weight loss.