PILOT FEASIBILITY DOSE ESCALATION STUDY USING INTRACEREBRAL MICRODIALYSIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用微透析评估原发性或转移性脑肿瘤患者接受替西罗莫司和替莫唑胺给药后脑内细胞因子水平的变化的初步剂量递增研究。 这两种化疗药物在实验室和动物研究中都显示出对脑肿瘤的活性。 本研究的目的是评估使用微透析导管确定在一段时间内有多少替西罗莫司和替莫唑胺保留在大脑中的可行性，以及这些药物随着时间的推移对与脑肿瘤相关的各种生物物质的影响。 此外，本研究将重点关注与替莫唑胺联合给药时，脑中替西罗莫司的量是否发生变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. pilot, does-escalation study using microdialysis to assess changes in intracerebral cytokine levels after administration of temsirolimus and temozolomide in patients with primary or metastatic brain tumors. Both of these chemotherapy drugs have shown activity against brain tumors in laboratory and animal studies. The purpose of this study is to evaluate the feasibility of using a microdialysis catheter in determining how much temsirolimus and temozolomide remain in the brain over a period of time and the effects these drugs have on various biological substances associated with brain tumors over time. Additionally, this study will focus on whether the amount of temsirolimus in the brain changes when given in combination with temozolomide.