ASSESSING THE PREVALENCE OF THE BK, CMV, & ADENOVIRUS INFECTIONS IN PED PTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项试验的目的是评估BK、CMV和腺病毒在接受造血干细胞移植的儿童患者中的流行率。我们将对接受造血干细胞移植(HSCT)的儿童患者的尿液和血液中BK、CMV和腺病毒的存在和水平进行经度分析。我们期望BK、CMV和腺病毒水平与以下因素相关：1)基础疾病(恶性与遗传性)，2)既往药物治疗，3)移植类型(兄弟姐妹、无关供者、脐带血、单倍体相合)，4)出血性膀胱炎或其他可能的BK、CMV或腺病毒相关疾病，5)当前抗病毒治疗，6)免疫功能恢复，7)免疫抑制强度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this trial is to assess the prevalence of the BK, CMV, and adenovirus in pediatric patients undergoing hematopoietic stem cell transplantation. We will perform longitude analysis of the presence and levels of BK, CMV, and adenovirus in the urine and blood of pediatric patients undergoing hematopoietic stem cell transplant (HSCT). We expect to correlate levels of BK, CMV, and adenovirus with the following: 1) underlying disease (malignant vs. genetic), 2) prior medications, 3) transplant type (sibling, unrelated donor, cord blood, haploidentical), 4) hemmorhagic cystitis or other possible BK, CMV, or adenovirus virus-related disease, 5) inter-current anti-viral therapy, 6) immune function recovery, and 7) immune suppression intensity.