GENOMIC AND PROTEOMIC DETERMINANTS OF LOWER EXTREMITY REVASCULARIZATION FAILURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 拟议的人类研究计划利用了佛罗里达大学的几个优势，其中最重要的是炎症生物学和外科科学实验室，该实验室在将功能基因组学和蛋白质组学应用于人类疾病方面拥有公认的专业知识。利用这些资源，这项研究旨在检验这样一个假设，即血管干预后的全身炎症反应会影响负责血管修复和适应的局部环境。人们的预期是，这种反应在所有患者中并不是一致的，而是受到某些术前遗传倾向或单核细胞功能的不同围手术期调节的调节，这些调节推动血管反应向闭塞性适应不良表型转变。早期干预失败，复发的下肢缺血和对生活质量的负面影响是潜在的结果。外周动脉闭塞疾病是一个重要的国家卫生保健问题，通过这项工作获得的信息将导致改进现有的下肢血管重建方法的新策略。它还将在更广泛的范围内为周围血管疾病的全面管理提供新的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed human research initiative takes advantage of several strengths at the University of Florida the most important of which is the Laboratory of Inflammation Biology and Surgical Science with recognized expertise in the application of functional genomics and proteomics to human disease. Using these resources, the study aims to test the hypothesis that the systemic inflammatory response following vascular intervention influences the local milieu responsible for vascular repair and adaptation. The expectation being that this response is not uniform in all patients, but rather, is modulated by either some preoperative genetic predisposition or differential periprocedural regulation of monocyte function that drives the vascular response towards an occlusive maladaptive phenotype. Early intervention failure with recurrent lower extremity ischemia and a negative impact on quality of life is the potential result. Peripheral arterial occlusive disease is a significant national health care concern and the information gained through this work will lead to new strategies to improve existing approaches to lower extremity revascularization. It will also provide new knowledge in the overall management of peripheral vascular disease on a significantly broader scope.