Developing and Improving Institutional Animal Resources

描述（由申请人提供）：重要的生物医学研究和科学数据的完整性依赖于优秀的动物护理。阿拉巴马大学伯明翰分校（UAB）动物护理和使用计划致力于根据公认的标准以合理的成本提供和保持始终如一的高质量，健康动物的长期目标，同时为员工提供安全健康的工作场所。最近的教师招募使用大型动物和继续现有的研究项目导致了严重的大型动物住房危机。本申请的具体目的是：(1)通过为大型动物提供适当的住房，为狗提供室外运动区域，保持健康的大型动物（狗、非人灵长类动物、猪）；(2)丰富工作人员的心理健康，为与他们亲密的狗提供户外锻炼的机会；(3)通过翻新/重新激活5000平方英尺的大型动物住房和支持空间（库克斯普林斯大型动物设施，CSLAF）来控制调查人员的成本。这个额外的空间将允许一个狗繁殖群体（30-40只狗）的长期住房，这是一个宝贵的国家资源，犬血液疾病和干细胞资源（CBD&SCR）。CBD&SCR为研究血友病、贫血和循环造血的机制和治疗的研究人员（UAB和其他机构）提供资源。在改造后的空间中，这个群体的住宿将允许现有的UAB大型动物研究人员维持研究时间表。21名UAB研究人员和其他机构的10名研究人员将从拟议的翻新中受益，他们有61个小灵通项目（每年2230万美元，活跃）和19个待决项目（2220万美元）。

DESCRIPTION (provided by applicant): Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high quality, healthy animals according to accepted standards at reasonable cost while providing a safe and healthy workplace for personnel. Recent faculty recruits using large animals and continued existing research programs has resulted in a severe large animal housing crisis. The specific aims of this application are to (1) maintain healthy large animals (dogs, nonhuman primates, pigs), by providing appropriate housing for large animals, with access to outdoor exercise areas for dogs; (2) Enrich personnel mental health allowing opportunity for dogs with which they have bonded to exercise outdoors and (3) contain costs for investigators by the renovation/reactivation of 5000 nsf of large animal housing and support space (Cook Springs Large Animal Facility, CSLAF). This additional space will allow long term housing of a dog breeding colony (30-40 dogs) that is a valuable national resource, Canine Blood Disorders and Stem Cell Resource (CBD&SCR). The CBD&SCR provides resources to investigators (UAB and other institutions) studying mechanisms and treatments of hemophilia, anemia, and cyclic hematopoiesis. The accommodation of this colony in the renovated space will allow existing UAB large animal researchers to maintain research schedules. Twenty-one UAB investigators and 10 investigators at other institutions with 61 PHS projects ($22.3 M annual, active) and 19 pending projects ($22.2M) will benefit from the proposed renovation.