Upgraded equipment and expansion of cage wash facilities.

描述（由申请人提供）：国家犹太医学和研究中心是一家小型，私立，非营利性医院，根据美国新闻和世界报道，在过去10年中，该医院已成为美国顶级呼吸医院。为了增加该机构的声望，国家犹太研究人员在NIH的成功率令人印象深刻 为这种规模的机构提供资金。许多研究者在他们的工作中使用动物模型。目前，超过75%的主要研究者使用生物资源中心（BRC）通过PHS获得资金。这笔资金主要用于支持转基因小鼠模型的研究。由于需要在现场繁殖和维护这些模型，小鼠数量激增。此外，该机构还进行了大量招聘，以实现2007年春季公布的10年战略计划的目标。这些因素加在一起 导致布拉迪斯拉发区域中心普遍拥挤，住房达到BSL-2级。由于额外的教师招聘和现有研究项目的增加，预计在未来2-3年内拥挤情况将恶化。为了确保最高质量的护理，国家犹太人在过去两年中投入了100多万美元用于改善BRC，并计划在未来1-2年内再投入50万美元。然而，由于《战略计划》所产生的项目，整个机构的资源都很紧张，因此很难获得除此之外的额外资金。因此，本申请旨在加强National Jewish在过去2年中已经做出的改进，并计划在未来1-2年内做出改进，申请资金用于额外的散装灭菌器、生物安全柜和高密度通风笼和机架。

DESCRIPTION (provided by applicant): National Jewish Medical and Research Center is a small, private, non-profit hospital that has developed an international reputation as the top Respiratory Hospital in the United States the past 10 years according to U.S. News and World Report. To add to the prestige of the institution, National Jewish researchers have an impressive success rate with NIH grant funding for an institution of its size. Many of these investigators use animal models in their work. Currently, greater than 75% of the Principal Investigators using the Biological Resource Center (BRC) have funding through the PHS. This funding mainly supports research with genetically modified mouse models. Due to the requirement to breed and maintain these models on site, there has been an explosion of the mouse population. In addition, there has been heavy recruitment to the institution to fulfill the goals of the 10 year Strategic Plan unveiled in the spring of 2007. Together, these factors have led to crowding in general and BSL-2 level housing in the BRC. Crowding is expected to worsen over the next 2-3 years due to additional faculty recruitment and increases in existing research programs. To ensure the highest quality of care, National Jewish has put over a million dollars into improvements of the BRC over the past 2 years and is planning on spending an additional half million dollars over the next 1-2 years. However, additional funding beyond this is difficult to secure as resources are tight across the entire institution, due to projects resulting from the Strategic Plan. Therefore, this application seeks to enhance the improvements that National Jewish has already made over the past 2 years, and is planning to make over the next 1-2 years, by requesting funds for an additional bulk sterilizer, biological safety cabinets, and high density ventilated caging and racks.