Intraepithelial lymphocyte development and function in the intestine

本研究旨在更好地了解肠道内稳态的维持和必要的修复过程。该项目将产生关于肠道免疫细胞（称为上皮内淋巴细胞（IEL））如何与肠道上皮细胞，神经元和肠道微生物接触以促进稳态和修复的新知识。该项目的预期成果将是确定未来药物和疫苗开发的新分子，以改善哺乳动物的肠道健康和疫苗接种。这将通过改善对癌症、肠道感染的保护和提高生产力，为澳大利亚人口和畜牧业带来重大利益。

This study aims to better understand the homeostatic maintenance and essential repair processes in the intestine. This project will generate new knowledge of how immune cells of the intestine, known as intraepithelial lymphocytes (IELs), engage with intestinal epithelial cells, neurons and commensal microbes to promote homeostasis and repair. Expected outcomes of this project will be identification of new molecules for future drug and vaccine development to improve gut health and vaccination in mammals. This should provide significant benefits to the Australian population and livestock industry through improved protection against cancer, intestinal infections and increased productivity.