IL-6 Regulation of Hippocampal Synaptic Function

描述（由申请人提供）：已显示神经免疫因子在正常CNS功能和与具有神经炎性成分的CNS疾病相关的认知功能障碍中发挥作用。我们对神经基质的了解是有限的，神经基质介导的认知问题与神经炎症。这一领域的进展将需要对神经免疫因子与介导正常脑功能的细胞和分子机制之间的相互作用有基本的了解。拟议的研究重点关注这一问题，因为它与CNS疾病有关。公共卫生相关性：神经免疫因子已被证明在正常CNS功能和与具有神经炎症成分的CNS疾病相关的认知功能障碍中发挥作用。我们对神经基质的了解是有限的，神经基质介导的认知问题与神经炎症。这一领域的进展将需要对神经免疫因子与介导正常脑功能的细胞和分子机制之间的相互作用有基本的了解。拟议的研究重点关注这一问题，因为它与CNS疾病有关。

DESCRIPTION (provided by applicant): Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders. PUBLIC HEALTH RELEVANCE: Project Narrative Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.