CHRONOBIOLOGIC MARKERS FOR LAB MEDICINE AND THERAPY

A.具体目标 最初的目标没有被修改。继续进行研究，重点放在三个主要的相互关联 主题，即通过生理监测进行风险检测来预防中风，实施这种 通过BIOCOS(大气球和宇宙对生物群的影响的研究)进行全球监测，以及 从而映射约每周一次、半周一次(CirCaseptan和CirCasemiseptan)等成分 光谱范围超过10个数量级。7天24小时的血压和心脏监测 强调比率是为了识别疾病风险综合征，涉及的变化不仅仅是平均水平 而不是血压和心率的变异性，包括它们的昼夜节律和昼夜节律 模式。所有参与中心的监测仍在继续。特别是日本乌拉苏和土佐的市民， 今年获奖者被邀请演讲的地方，正在放映，重点放在几个 通过问卷[59-62]评估的生活质量指数[59-62]t以及可获得结果的地方。 非光性太阳对生理学和病理学的影响的研究一直在进行。新发现 包括在新的和更新的血液记录中检测到的大约1.3年的成分的演示 压力和心率跨越长达40年，与报道的太阳风速1.3年一次的周期一致 作者：John D.Richardson[40，41，54，91,138,158,164,173]。值得注意的是，大约1.3年的组成部分 观察明尼苏达州和其他几个地区的心脏性猝死发生率(ICD10,146.1) 地理位置，在没有1年同步组件的情况下。新的非光性的映射 以及已知的光周期[87,127,133,153]。这项工作催生了新的 时间学领域和《天文学图集》的开始，这是接下来几年要探讨的主要主题 好几年了。 约-每周和半周的组成部分现在通常根据7天/24小时的配置文件进行评估 每隔30分钟全天候测量血压和心率。中的数据库摘要 T方括号中的数字是指按获奖者列出的出版物下列出的图书。 Urausu市(日本北海道)在抑郁症患者中发现了更明显的周围赛普坦变化。 主题[59]。 总之，在获奖者的活动中探讨了三个主要主题，即 1.开发新的疾病风险症状的治疗模式； 2.评估非光性和光性对生命形式的影响，包括太阳活动的影响 地磁学对人体生理和病理的影响；这种低频分量的映射是 开始了，奠定了新的计时学领域的基础； 3.绘制选定物种的天文图谱，重点放在生物日的相对重要性上 生物周和自然年之间的对比。

A. SPECIFIC AIMS The original aims have not been modified. Research continued with focus on three major inter-related topics, namely stroke prevention by risk detection via physiological monitoring, the implementation of such monitoring worldwide via BIOCOS (the study of effects of the BlOsphere and the COSmos on biota), and thereby the mapping of about-weekly, half-weekly (circaseptan and circasemiseptan) and other components in spectra covering over 10 orders of magnitude. The 7-day/24-hour monitoring of blood pressure and heart rate was emphasized for the identification of disease risk syndromes involving alterations not only in mean values but in the variability of blood pressure and heart rate, including their circadian and circaseptan patterns. Monitoring continued at all participating centers. In particular, citizens of Urausu and Tosa, Japan, where the awardee was invited to lecture this year, are being screened with additional focus on several indices of quality of life assessed by questionnaires [59-62]t and where outcomes are becoming available. The study of non-photic solar effects on physiology and pathology has been pursued. New findings include the demonstration of an about 1.3-year component detected in new and updated records of blood pressure and heart rate spanning up to 40 years, matching the 1.3-year cycle in solar wind speed reported by John D. Richardson [40, 41, 54, 91, 138, 158, 164, 173]. An about 1.3-year component has notably been observed in the incidence of sudden cardiac death (ICD10, 146.1) in Minnesota and in several other geographic locations, in the absence of a 1-year synchronized component. The mapping of new non-photic as well as of known photic cycles has continued [87, 127, 133, 153]. This work led to the birth of the new field of chronomics and the start of an atlas of chronomes, the major topic to be pursued in the next few years. About-weekly and half-weekly components are now routinely assessed from the 7-day/24-hour profiles of blood pressure and heart rate measured around the clock at 30-min intervals. Summaries of data bases in tNumbers in square brackets refer to titles listed under Publications by awardee. the city of Urausu (Hokkaido, Japan) revealed a more pronounced circaseptan variation among depressive subjects [59]. In summary, three major themes in the activities of the awardee were pursued, namely 1. the development of treatment modalities of new disease risk syndromes; 2. the assessment of non-photic as well as photic effects on life forms, including influences from helio- and geomagnetics on human physiology and pathology; the mapping of such low frequency components was started, underlying the new field of chronomics; and 3. the mapping of chronomes in selected species, with focus on the relative importance of the biological day vs. the biological week and of the transyear vs. the calendar year.