ENDOMETRIOSIS IN RHESUS MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的了解恒河猴子宫内膜异位症的患病率和家族聚集性。 子宫内膜异位症发生在几种有月经周期的非人类灵长类动物中。从1978年到2002年，我们发现了144只患有子宫内膜异位症的恒河猴。我们建立了一个庞大的多代系谱和9个核心家庭，其中包括1,602名女性。子宫内膜异位症的患病率随年龄增长而增加。与未患子宫内膜异位症的动物相比，患子宫内膜异位症的动物之间的平均亲属关系系数显著更高，这有力地提示了子宫内膜异位症的家族聚集性。我们发现，与母亲同父异母的兄弟姐妹和父亲同父异母的兄弟姐妹相比，全同胞的复发风险更高。患病母亲的分离比与非患病母亲相比无显著差异。这些结果支持恒河猴子宫内膜异位症的家族聚集性，并表明这是研究遗传方式、潜在遗传易感基因定位和环境因素影响的一种有前景的动物模型。谱系和遗传信息的评估仍在继续。在本报告期间，我们从存档的和新鲜的组织样本中提取DNA，用于全基因组关联研究。该项目目前正在扩大，通过我们的CTSA和对其他NPRC殖民地子宫内膜异位症流行率的网络调查，包括更多的临床合作者。这项研究使用了WNPRC动物服务和老龄资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate the prevalence and familial aggregation of endometriosis in rhesus macaques. Endometriosis occurs in several non-human primate species that have menstrual cycles. Between 1978 and 2002, we identified 144 rhesus macaques with endometriosis. We established a large multigenerational pedigree and nine nuclear families comprising 1,602 females. Prevalence of endometriosis increased with age. Familial aggregation of endometriosis was strongly suggested by a significantly higher average kinship coefficient among affected animals compared with those unaffected. We saw a higher recurrence risk for full siblings when compared to maternal half siblings and paternal half sibs. The segregation ratio among affected mothers was not significantly higher compared with unaffected mothers. The results support familial aggregation of endometriosis in rhesus macaques and indicate that this is a promising animal model for investigating the mode of inheritance, the location of potential genetic susceptibility loci and the influence of environmental factors. Evaluation of pedigree and genetic information is continuing. In the current report period, we isolated DNA from archived and fresh tissue samples for a genome-wide association study. The project is currently expanding to include additional clinical collaborators through our CTSA and a web-based survey of the prevalence of endometrisosis in the colonies of the other NPRCs. This research used WNPRC Animal Services and Aging Resources.