PHARMACOLOGICAL STRATEGIES FOR AUGMENTING EXTINCTION OF DRUG SEEKING

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project builds on advances in cognitive-behavioral therapy in conjunction with pharmacological modulation of glycine, an obligatory co-transmitter at the glutamate receptor complex. The research specifically investigates the ability of selective glycine site partial agonists and glycine transport inhibitors to accelerate extinction of cocaine-seeking behavior, reduce subsequent reactivity to cocaine cues, and inhibit re-acquisition of cocaine self-administration. The approach serves as a translational interface for development of effective pharmacotherapies to augment extinction therapy for cocaine abuse.