PHARMACOLOGICAL STRATEGIES FOR AUGMENTING EXTINCTION OF DRUG SEEKING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目以认知行为疗法(线索暴露/消退疗法)与药物疗法相结合的进展为基础，研究甘氨酸能药物的使用，以加速寻求可卡因行为的消失，并减少对可卡因自我给药的复发。该方法为开发有效的药理辅助消退疗法提供了一个过渡接口。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project builds on advances in cognitive-behavioral therapy (cue-exposure/extinction therapy) in conjunction with pharmacotherapy to investigate the use of glycinergic drugs to accelerate extinction of cocaine-seeking behavior and to reduce relapse to cocaine self-administration. The approach serves as a transitional interface for development of effective pharmacological adjuncts to extinction therapy.