MOLECULAR GENETIC MARKERS IN PRIMATE DISEASE MODELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 非人灵长类动物是生物医学研究的关键组成部分，是许多人类疾病的动物模型。关于非人类灵长类动物模型的遗传信息的增加将扩大与疾病相关的研究机会。随着灵长类动物基因特征的研究取得进展，未来使用这些物种的研究项目将能够更全面地研究遗传学和疾病之间的关系。该项目的第一个目标是在现有的狒狒遗传连锁图谱上增加新的遗传多态。第二个目标是识别恒河猴的其他遗传多态，并将它们添加到恒河猴连锁图谱中。我们已经确定了新的遗传标记，以填补狒狒连锁图谱中的几个现有空白。该项目将提高狒狒和恒河猴在各种疾病研究中的价值，这些疾病与心脏病、肥胖症、精神障碍、骨质疏松症和包括艾滋病在内的传染病有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonhuman primates are a critical component of biomedical research, as animal models for many human diseases. Increased genetic information about nonhuman primate animal models will expand opportunities for disease-related research. As the genetic characterization of primates progresses, future research projects using these species will be able to more fully investigate relationships between genetics and disease. The first objective of this project is to add new genetic polymorphisms to the existing baboon genetic linkage map. The second objective is to identify additional genetic polymorphisms in rhesus monkeys and add them to the rhesus linkage map. We have identified new genetic markers to fill several existing gaps in the baboon linkage map. This project will improve the value of baboons and rhesus for a wide variety of disease studies related to heart disease, obesity, psychiatric disorders, osteoporosis and infectious disease, including AIDS.