CONTINUATION OF THE CONSORTIUM FOR THE LONGITUDINAL EVALUATION OF AFRICAN-

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究将完成对400名患有早期RA的非洲裔美国人的纵向评估，来自先前的CLEAR研究，其中收集了约200名年龄，性别和地理位置匹配的健康非洲裔美国人对照样本。 此外，将提出一种横断面方法，以编制600名长期RA的非裔美国人的广泛人口统计学、社会经济学、临床和影像学数据。 将收集基因组DNA、用于基因表达研究的RNA和血清，以全面分析影响非裔美国人RA的因素。 一旦完成，CLEAR将为科学界提供一个独特和宝贵的资源，以确定影响疾病发生和结果的遗传和非遗传因素。 这种资源将，反过来，允许许多悬而未决的问题，关于RA在非洲裔美国人得到解决。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will serve to complete the longitudinal evaluation of 400 African-Americans with early RA, from the previous CLEAR study in which ~200 healthy African-American controls matched for age, sex, and geographic location samples have been collected. In addition, a cross-sectional approach to compile extensive demographic, socioeconomic, clinical, and radiographic data on 600 additional African-Americans with longstanding RA will be proposed. Genomic DNA, RNA for gene expression studies, and serum to allow a comprehensive analysis of factors influencing RA in African-Americans will be collected. When complete, CLEAR will provide a unique and valuable resource for the scientific community to identify genetic and non-genetic factors that influence disease occurrence and outcomes. This resource will, in turn, allow many unanswered questions regarding RA in African-Americans to be addressed.