CLINICAL TRIAL: COFFEE AND GLUCOSE TOLERANCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项临床研究提案的总体目的是论证随机干预研究的可行性，比较饮用咖啡因咖啡、无咖啡因咖啡或水对糖代谢的影响。如果成功，这项研究将为咖啡摄入量、体脂和葡萄糖耐量的长期明确试验奠定基础。这项研究的具体目的是1)评估随机参与者对其分配的治疗的坚持程度；2)确定饮用咖啡因和无咖啡因咖啡对体重、负荷后血糖浓度和胰岛素敏感性标记物的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this clinical research proposal is to demonstrate the feasibility of randomized intervention study comparing the effects of consumption of caffeinated coffee, decaffeinated coffee or water on glucose metabolism. If successful, this study will form the basis for a long term definitive trial of coffee consumption, body fat, and glucose tolerance. Specific aims of this study are to 1) assess the adherence of randomized participants to their assigned treatment; 2) to determine the effect of caffeinated and decaffeinated coffee consumption on body weight, postload glucose concentrations and markers of insulin sensitivity.