EFFECT OF LOW CARBOHYDRATE DIET ON SYMPTOMS OF IBS: A PROSPECTIVE PILOT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的目的是前瞻性地确定：1）极低碳水化合物饮食对肠易激综合征（IBS-D）患者生活质量和胃肠道症状的影响; 2）确定症状改善的可能生理相关性，如与餐后5-HT和5-HIAA释放、体重减轻和纤维含量相关。 这些预期的发现可能会导致更好地了解饮食在IBS中的作用，并最终有助于改善患者护理。 30名志愿者将在UNC-CH入组。IBS严重程度指数将用于确定合格性。 所有参与者将被给予两周的富含碳水化合物的饮食，然后是四周的非常低的碳水化合物饮食。 结果测量将包括使用每日日记卡的症状（标准化腹痛、大便形式和频率）、每日功能状态、患者生活质量以及餐后5-HT和5-HIAA的释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our purpose is to prospectively determine 1) the effect of a very low carbohydrate diet on quality of life and gastrointestinal symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS-D); and 2) to determine possible physiological correlates of symptom improvement, as related to post-prandial 5-HT and 5-HIAA release, weight loss and fiber content. These expected findings could lead to a better understanding of the role of diet in IBS and may ultimately help improve patient care. Thirty volunteers will be enrolled at UNC-CH. An index of IBS severity will be used to determine eligibility. All participants will be given two weeks of meals for a carbohydrate-rich diet, followed by four weeks of a very low carbohydrate diet. Outcome measures will include symptoms (standardized abdominal pain, stool form and frequency) using daily diary cards, daily function status, patient quality of life, and post-prandial release of 5-HT and 5-HIAA.