ROLE OF COMPLEMENT RECEPTOR 2 IN SYSTEMIC LUPUS ERYTHEMATOSUS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 补体受体2是抗体产生细胞上的一种蛋白质，被认为在狼疮中很重要。 我们已经证明，这种蛋白质的基因在狼疮动物模型中是异常的，这为它导致狼疮提供了强有力的证据。 这种受体在狼疮患者的血细胞中也存在较低水平。 在这项研究中，我们想确定受体的这种变化是否与狼疮患者的病情有关。 我们将在一年内每隔3个月观察狼疮患者血细胞上这种受体的数量，看看当狼疮更活跃时，这种受体的数量是否会下降。 我们还将试图找出为什么水平下降，因为这可能有助于我们了解是什么导致狼疮，并找到更好的治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Complement receptor 2 is a protein on antibody-producing cells believed to be important in lupus. We have shown that the gene for this protein is abnormal in an animal model of lupus, providing strong proof that it causes lupus. This receptor is also present at lower levels on the blood cells of people with lupus. In this study, we want to determine whether this change in the receptor is related to how sick a person with lupus is. We will look at the amount of this receptor on the blood cells of people with lupus at 3 month intervals for one year to see if the amount goes down when their lupus is more active. We will also try to sort out why the levels go down since this may help us understand what causes lupus and find better treatments.