Specific elimination of anti-DNA antibody-producing cells in systemic lupus erythematosus.
特异性消除系统性红斑狼疮中产生抗 DNA 抗体的细胞。
基本信息
- 批准号:59870026
- 负责人:
- 金额:$ 3.2万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Developmental Scientific Research
- 财政年份:1984
- 资助国家:日本
- 起止时间:1984 至 1985
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The specific manipulation of anti-DNA antibody production is one of the prefered treatment of systemic lupus erythematosus (SLE). For this purpose, we induced DNE-specific tolerance in vitro using DNA-Dglutamic acid-D-lysine(DNA-D-GL).The addition of the tolerogen reduced markedly the in vitro production of spontaneously occuring anti-ds and/or anti-ss DNA antibodies by SLE lymphocytes. The unresponsiveness was DNA-specific.We also used monoclonal anti-idiotypic (Id) antibodies which were conjugated with neocarzinostatin (NCS), a cytotoxic agent. Human B cell clones, which produce anti-DNA autoantibodies, were killed by by in vitro treatment with anti-Id-NCS conjugates, while clones expressing an Id with irrelevant specificity were unaffected. Anti-Id-NCS also specifically suppressed anti-DNA autoantibodyproductin in vitro by human lymphocytes.This approach will have a significant advantages in aborting clones, and will result in a potent therapeutic treatment for SLE.
特异性抗DNA抗体的产生是治疗系统性红斑狼疮(SLE)的首选方法之一。为此,我们在体外用DNA-D-谷氨酸-D-赖氨酸(DNA-D-GL)诱导DNE特异性耐受,该耐受原的加入显著减少了SLE淋巴细胞在体外自发产生的抗ds和/或抗ss DNA抗体。无反应性是DNA特异性的。我们还使用了与细胞毒剂新卡西汀(NCS)偶联的抗独特型(ID)单抗。产生抗DNA自身抗体的人B细胞克隆可被抗ID-NCS结合物体外杀伤,而表达无关特异性的ID的克隆不受影响。抗ID-NCS在体外也能特异性地抑制人类淋巴细胞产生的抗DNA自身抗体,这种方法在流产克隆方面将具有显著的优势,并将为SLE的治疗提供一种有效的治疗方法。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SASAKI Takeshi其他文献
SASAKI Takeshi的其他文献
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The mechanism of atherosclerotic plaque disruption in experimental animal model. The concept of the involvement of cathepsins.
实验动物模型中动脉粥样硬化斑块破坏的机制。
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21700447 - 财政年份:2009
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The mechanism of atherosclerotic plaque disruption in apoE-deficient mice. The concept of the involvement of inflammation
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19700366 - 财政年份:2007
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A study of systems of differential equations associated with projectively minimal surfaces
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19540080 - 财政年份:2007
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$ 3.2万 - 项目类别:
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Study of transformations of Lie-minimal surfaces
李极小曲面变换的研究
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17540076 - 财政年份:2005
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$ 3.2万 - 项目类别:
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