THE EFFECT OF ETHANOL ON OVERNIGHT GLUCOSE REGULATION IN TYPE 2 DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 中等剂量的乙醇会导致老年人夜间的低血糖易感性，胰岛素需要2型糖尿病患者通过干扰一个或几个对预防低血糖至关重要的生理过程来实现。这项研究中研究的变化是对睡眠中正常发生的低血糖的不足的反调节反应的加剧。 目的：比较12例老年健康老年人和12例需要胰岛素治疗的老年2型糖尿病患者口服和静脉注射中等剂量乙醇或安慰剂对睡眠中胰岛素诱导的低血糖恢复和反调节激素释放的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moderate doses of ethanol cause overnight hypoglycemic vulnerability in elder, insulin requiring patients with type 2 diabetes by interfering with one or several of the physiologic processes critical to the defense against hypoglycemia. The alteration investigated in this study is exacerbation of the deficient counterregulatory response to hypoglycemia that occurs normally during sleep. To compare the overnight effects of moderate doses of both orally and intravenously administered ethanol or placebo on counterregulatory hormone release and recovery from insulin-induced hypoglycemia during sleep among 12 elder healthy and 12 elder subjects with insulin requiring type 2 diabetes.