IMAGING THE DEVELOPMENT OF MEMORY STRAEGIES IN AGING

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们建议使用脑磁图或MEG检查情景记忆功能，沿着白色物质完整性的测量（即，MR形态测量、白色高信号的分类和FA的各向异性分数）和认知完整性（即，神经心理学测试），以证明健康的“成功”衰老与“正常”衰老有很大不同，因为后者可能包括高血压和糖尿病等病理过程，这些过程会增加痴呆症的风险。 这种区别的重要性在于，一些导致认知能力下降的病理过程是可以控制或预防的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use magnetoencephalography or MEG to examine episodic memory function, along with measures of white matter integrity (i.e., MR morphometry, classification of white matter hyperintensities and fractional anisotrophy of FA) and cognitive integrity (i.e., neuropsychological tests), to demonstrate that healthy 'successful' aging is quite different from 'normal' aging since the latter may include pathological processes such as hypertension and diabetes which can increase the risk for dementia. The importance of this distinction is that some pathological processes contributing to cognitive decline can be controlled or prevented.