RAPIDITY OF PROGESTERONE SUPPRESION OF LH PULSE FREQUENCY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青春期LH表现出昼夜变化，夜间LH脉冲频率和幅度增加。我们假设这些LH增加刺激卵巢P和E2，这反过来又抑制LH脉动在第二天。为了使这一假设可行，这些性类固醇必然具有急性作用，在数小时而不是数天内影响GnRH脉冲频率的变化。P抑制GnRH频率的速度尚不清楚。我们建议进一步评估这一点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LH exhibits diurnal changes during puberty, with nocturnal increases in LH pulse frequency and amplitude. We hypothesize that these LH increases stimulate ovarian P and E2, which in turn suppresses LH pulsatility during the following day. For this hypothesis to be viable, these sex steroids would necessarily have acute actions, effecting GnRH pulse frequency changes over hours rather than days. The rapidity with which P supresses GnRH frequency is unknown. We propose to assess this further.