PROTEOMICS OF CEREBROSPINAL FLUID IN CFS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们对CFS、纤维肌痛(FM)和波斯湾战争病(PGI)的受试者和一组健康志愿者进行了腰椎穿刺术(“脊椎抽吸”)。CFS和相关小组在他们大脑周围的液体中有一组独特的蛋白质。这是非常令人兴奋的，因为这是CFS、FM和PGI是“真正的”疾病的有力证据。我们发现的蛋白质可能会成为这些综合征的诊断标记物，并成为CFS/FM/PGI疾病测试的一部分。他们还提供了对出错的分子机制的见解，并指出了潜在的治疗方法。然而，首先，我们必须对患有CFS的妇女和健康对照妇女进行更多的脊椎抽液。 我们提供一项新的付费临床研究，在乔治敦大学医学中心住一晚，腰椎穿刺术和其他更简单的测试。我们正在招募50名患有CFS的女性和50名健康的女性，她们希望帮助找到治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have performed lumbar punctures ("spinal taps") on CFS, fibromyalgia (FM), and Persian Gulf War Illness (PGI) subjects and a group of healthy volunteers. The CFS and related groups had a unique set of proteins in the fluid surrounding their brains. This is very exciting because it is strong evidence that CFS, FM, and PGI are "real" diseases. The proteins we found may turn out to be diagnostic markers for these syndromes, and become part of a test for CFS/FM/PGI illnesses. They also offer insights into the molecular mechanisms that go awry, and point towards potential treatments. First, however, we must perform more spinal taps on women with CFS and health control women. We offer a new, paid, clinical research study with a 1 night stay at Georgetown University Medical Center, lumbar puncture and other, more simple tests. We are recruiting 50 women with CFS and 50 healthy women who want to help find a cure.