Innovations in Pediatric Pain Research

描述(由申请人提供)：本次申请以患者为中心的研究生涯中期研究员奖的具体目标是1)使用创新技术来改进功能结果的测量，并为患有慢性疼痛的青年提供心理干预，以及2)为候选人提供必要的保护时间和资源，以指导正在进行儿科疼痛临床研究的博士后研究员和初级教员。这位候选人的计划研究集中在开发创新方法来评估和治疗慢性疼痛、残疾和睡眠问题。在获奖期间，候选人将在一项关于睡眠-觉醒行为的新型纵向研究中，完成使用创新技术改进疼痛和睡眠测量的研究。她将开展新的研究，以检验互联网家庭认知行为干预在改善患有慢性疼痛的青少年功能结果方面的有效性。该候选人有为研究生、博士后研究员和心理学和医学初级教员提供指导的既定记录。该奖项分配的更多时间将使候选人有机会专注于培训更多的博士后研究员和教师。该研究计划包括两个项目：NIH/NICHD RO1《慢性疼痛青少年的睡眠-觉醒障碍》和一项新的互联网心理治疗慢性疼痛临床试验《基于网络的CBT对患有慢性疼痛的青少年客观功能结果的影响》。初级临床研究人员的指导计划包括在监督下参与候选人正在进行的研究；进行独立研究；以及在专业活动和实现专业里程碑方面的经验。通过俄勒冈健康与科学大学(OHSU)的人类调查计划(OHSU)，NIH K30计划为受训者提供正式的教学计划，其中包括研究设计、随机对照试验、伦理学/人类受试者、拨款撰写和高级分析方法等研讨会。OHSU为这一奖项提供了一个理想的环境，因为它已经建立了合作关系，致力于以患者为中心的研究，以及强大的临床翻译研究中心的存在。相关性(见说明)：候选人研究计划的公共卫生目标是为患有慢性疼痛和睡眠问题的青少年开发创新的治疗方法，以提高当前的护理标准，并将疼痛和残疾的长期问题降至最低。此外，候选人寻求在这一领域培养下一代以患者为导向的研究人员。

DESCRIPTION (provided by applicant): The Specific Aims of this application for a Midcareer Investigator Award in Patient-Oriented Research are 1) to use innovative technologies to Improve measurement of functional outcomes and to deliver psychological interventions to youth with chronic pain, and 2) to provide the candidate protected time and resources necessary to mentor postdoctoral fellows and junior faculty members who are pursuing clinical Investigation in pediatric pain. The candidate's programmatic research has focused on developing innovative methods to assess and treat chronic pain, disability, and sleep problems. During the course of this award, the candidate will complete research studies using innovative technologies to improve measurement of pain and sleep in a novel longitudinal study of sleep-wake behaviors. She will develop new research to examine the efficacy of an internet family cognitive-behavioral intervention on improving functional outcomes in adolescents with chronic pain. The candidate has an established track record of providing mentorship to graduate students, postdoctoral fellows, and junior faculty in psychology and medicine. The increased time allotted by this award will give the candidate the opportunity to focus on training additional postdoctoral fellows and faculty. The Research Plan includes two projects: an NIH/NICHD RO1 "Sleep-wake disturbances in adolescents with chronic pain," and a new clinical trial of an internet delivered psychological treatment for chronic pain "Effect of Web-based CBT on Objective Functional Outcomes in Youth with Chronic Pain." The Mentoring Plan for beginning clinical Investigators consists of supervised participation in the candidate's ongoing research; conduct of independent research; and experience in professional activities and achieving professional milestones. A formal didactic program is available to mentees through the Human Investigations Program at Oregon Health & Science University (OHSU), a NIH K30 program, with seminars on study design, randomized controlled trials, ethics/human subjects, grant writing, and advanced analytic approaches. OHSU provides an ideal setting for this award because of the established collaborations, commitment to patient-oriented research, and the presence of a strong Clinical Translational Research Center. RELEVANCE (See instructions): The public health goals of the candidate's research program are to develop innovative treatments for youth with chronic pain and sleep problems that can improve the current standard of care and minimize long-term problems with pain and disability. In addition, the candidate seeks to train the next generation of patient-oriented researchers in this area.