DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 代谢综合征（MetS）的两个定义特征是高甘油三酯（TG）和低HDL（MetS的血脂异常）。在体重稳定时，对于最适合管理血脂异常和代谢综合征血管反应性受损的膳食脂肪和碳水化合物比例没有共识。 根据最近的研究，与极高和极低脂肪饮食相比，脂肪和碳水化合物摄入量适中的饮食可能对代谢综合征更有益。超重和胰岛素抵抗的人似乎比正常体重的人对饱和脂肪限制的反应更少。与这些发现相一致的是，在观察性研究中，摄入高脂肪饮食的人患冠心病的几率较低。 本研究将采用在UW GCRC代谢厨房制备的食物，在随机、4周、交叉、喂养研究设计中比较两种饮食对脂蛋白和血管的影响。饮食将包含40%的脂肪，45%的碳水化合物或20%的脂肪，65%的碳水化合物与等量的蛋白质（15%）和饱和脂肪（8%）。 体重将保持稳定。 将对72名男性和女性进行随机化，以产生至少60名完成研究的受试者，脱落率为20%。 当从GCRC取食物时，每周测量两次体重和其他生命体征。在第0、3和4周测量脂蛋白脂质。在第0周和第4周测量载脂蛋白B和A-I、LDL浮力、葡萄糖、胰岛素、脂联素、炎症细胞因子和血流介导的肱动脉反应性。4个月的延长期将在营养师咨询下测试第二次饮食分配效果的持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two defining features of the metabolic syndrome (MetS) are high triglycerides (TG) and low HDL (dyslipidemia of MetS). At weight stability, there is no consensus on the dietary fat and carbohydrate proportions best suited for managing the dyslipidemia and the impaired vascular reactivity of MetS. In contrast to extreme high and low-fat diets, diets moderate in fat and carbohydrate intake may be more beneficial in MetS based on recent studies. Overweight and insulin resistant persons appear to be less responsive to saturated fat restriction than normal weight persons. Consistent with these findings are lower rates of coronary disease in persons ingesting higher fat diets in observational studies. This study will compare lipoprotein and vascular effects of two diets in a randomized, 4-week, crossover, feeding study design, using food prepared in the metabolic kitchen of the UW GCRC. Diets will contain 40% fat, 45% carbohydrate or 20% fat, 65% carbohydrate with equivalent protein (15%) and saturated fat (8%). Weight will remain stable. Seventy-two men and women will be randomized to yield a minimum of 60 finished subjects at a 20% drop out rate. Weight and other vital signs are measured twice weekly when food is picked-up from the GCRC. Lipoprotein lipids are measured at 0, 3 and 4 weeks. Apoproteins B and A-I, LDL buoyancy, glucose, insulin, adiponectin, inflammatory cytokines and flow-mediated brachial artery reactivity are measured at 0 and 4 weeks. A 4-month extension will test the durability of the effect of the second diet assignment under dietician counseling.