NEURODEVELOPMENT AMONG INFANTS WITH DEFORMATIONAL PLAGIOCEPHALY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 变形斜头症(DP)指的是颅骨不对称，被认为是由于外力塑造了可延展的婴儿头骨。可疑的原因包括产前因素(例如宫内窘迫)、产后事件(例如睡眠中的不变姿势)和/或潜在的神经病理。对患有痴呆症儿童的神经发育的初步研究发现了显著缺陷的证据，但方法问题限制了对这些研究的解释；对这些发现的潜在解释尚不清楚。进一步的研究是必要的，以完善病因假说，并为临床医生和父母提供关于DP的神经发育相关的准确信息。有几个因素表明有必要立即对这些问题进行研究：儿童发育迟缓率迅速上升(和/或家长对这种疾病的认识和担忧日益增加)，相关医疗手段(头盔和颅面外科手术)的普及，出现可预防的发育问题的可能性，以及与美国儿科学会“重返睡眠”运动之间的因果关系。在这项为期5年的纵向单中心研究中，我们将招募250名患有DP的婴儿和275名匹配的对照组婴儿，从6个月到36个月进行跟踪调查，以调查这些问题。一组DP病例将使用MRI(n=46)进行成像，并通过与NIH资助的另一项正常大脑发育研究共享数据来与对照组进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Deformational plagiocephaly (DP) refers to cranial asymmetry believed to be attributable to external forces molding the malleable infant skull. Suspected causal factors include pre-natal factors (e.g., intrauterine constraint), post-natal events (e.g., invariant positioning during sleep) and/or underlying neuropathology. Initial studies of the neurodevelopment of children with DP have found evidence for significant deficits, but methodological problems limit the interpretation of these studies; potential explanations for such findings are unclear. Further investigation is necessary to refine etiological hypotheses and to provide clinicians and parents with accurate information regarding the neurodevelopmental correlates of DP. Several factors indicate the need for rather immediate study of these issues: the rapidly increasing rate of DP (and/or increasing awareness of and parental worry about the condition), the proliferation of associated medical treatments (helmets and craniofacial surgery), the possibility of preventable developmental problems, and the implication of causal association with the American Academy of Pediatrics "Back to Sleep" campaign. In this 5-year, longitudinal, single-center study, we will investigate these issues by recruiting 250 infants with DP and 275 matched controls, following them from age 6 to 36 months. A subgroup of DP cases will be imaged using MRI (n= 46) and compared to controls by sharing data with another NIH-funded study of normal brain development.