A PHASE II, RANDOMIZED TRIAL OF AMPHOTERICIN B ALONE OR COMBINED WITH FLUCONA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究建议评价两性霉素B单独或与氟康唑联合治疗艾滋病相关隐球菌性脑膜炎的疗效。这是一项跨国家的第二阶段随机试验，受试者将从美国和泰国的多个地点招募。10名受试者将在南加州大学接受测试和监测。试验需要一段时间的输液，一段时间的口服，以及一段随访期。所有研究程序都将在GCRC进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to evaluate amphotericin B alone or combined with fluconazle in the treatment of AIDS-associated cryptococcal meningitis. This is a multi-national, phase II randomized trial in which subjects will be recruited from multiple sites in both the US and Thailand. 10 subjects will be tested and monitored here at USC. The trial requires a period of infusion, a period of ingestion by mouth, and a follow-up period. All study procedures will be performed in the GCRC.