HUMAN MODELS OF SICKLE CELL VASCULAR DAMAGE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在正常对照组和镰状细胞性贫血受试者中，将研究皮肤毛细血管血流量和血液氧气输送到深层组织的变化，以响应短暂的低氧。这些反应将被标准化，这样它们以后就可以用于研究可能改善血流和氧气输送的药物干预措施。血氧水平输送将通过磁共振成像测量，皮肤毛细血管血流量将使用激光多普勒血流测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changes in dermal capillary blood flow and blood oxygen deliver to deep tissue in response to a brief period of hypoxia will be studied in normal controls and subjects with sickle cell anemia. These responses will be standardized so they can later be used to study pharmacological interventions that may improve blood flow and oxygen delivery. Blood oxygen level delivery will be measured by magnetic resonance imaging and dermal capillary blood flow will be measured using laser-Doppler flow.