ADULT AIDS CLINICAL TRIALS GROUP LONGITUDINAL LINKED RANDOMIZED TRIALS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究是为了了解人体如何对艾滋病毒感染及其治疗作出反应。 该研究将研究的例子包括：1）几年内哪些药物组合效果最好; 2）哪些因素决定了帮助对抗感染和艾滋病毒的血细胞（T细胞）的数量; 3）药物组合的顺序是否影响结果; 4）长期服用药物会发生什么样的副作用和疾病（4年或更长时间）治疗艾滋病毒感染; 5）有多少人经历过这些副作用和疾病;以及6）长期血液中病毒（病毒载量）水平非常低或检测不到的人与病毒载量较高的人相比如何。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being done to learn how the body responds to HIV infection and its treatment over several years. Examples of things the study will look at include: 1) What combinations of drugs work best over several years; 2) What factors determine the amount of blood cells (T cells) that help fight infection and HIV; 3) If the order in which combinations of drugs are given affects outcome; 4) What kinds of side effects and illnesses occur during long-term (4 or more years) treatment of HIV infection; 5) How many people experience these side effects and illnesses; and 6) How people with very low or undetectable levels of virus in their blood (viral load) for a long time compare with those whose viral load is higher.