Biostatistics

生物统计学核心将为西雅图乳腺癌联合会提供必要的生物统计学支持 孢子调查员。核心将研究设计、数据收集、测量和分析与 关键的假设和问题，研究涉及基础科学的SPORE调查人员研究， 流行病学、人口研究和临床研究。生物统计学核心将为SPORE做出贡献 使命的具体目标如下： 1.研究设计：定义研究假设、研究人群和实验测量， 回答感兴趣的研究问题，避免系统性偏见，并确保 检测具有生物学意义的效应。 2.分析和解释：确定并实施适当的定量方法， 感兴趣的科学问题，并提供有效的统计推断的证据支持 各种研究假设。 3.必要时的方法学发展：修改现有方法并开发新的研究 在适当情况下，解决SPORE项目引起的问题的设计和方法 统计方法不够。 SPORE生物统计学家一直密切参与SPORE的项目。他们将继续 作为每个项目的共同研究者进行合作，以确保研究设计良好， 分析和解释。此外，核心将为SPORE调查人员提供咨询服务， 研究发展计划和职业发展计划下的项目。核心 调查人员拥有各种互补的专业知识，可以利用来自广泛领域的数据进行分析。 各种实验技术。对于其中一些技术，分析方法仍在不断发展。 核心研究人员是联盟生物统计研究小组的一部分，这些研究小组是以下领域的领导者： 生物标志物开发、计算生物学和生物信息学。综上所述，酷睿配备精良 以满足不同的需求，并解决乳腺孢子的翻译目标。

The Biostatistics Core will provide essential biostatistical support to Seattle Cancer Consortium Breast SPORE investigators. The Core links study design, data collection, measurements, and analysis to the critical hypotheses and questions studied by SPORE investigators whose research involves basic sciences, epidemiology, population studies, and clinical research. The Biostatistics Core will contribute to the SPORE mission through the following specific aims: 1. Study design: Define study hypotheses, study populations, and experimental measurements to answer research questions of interest, avoid systematic bias, and ensure a high likelihood of detection of biologically meaningful effects. 2. Analysis and interpretation: Identify and implement appropriate quantitative methods to address scientific questions of interest and provide valid statistical inferences about the evidence supporting the various study hypotheses. 3. Methodological development when needed: Modify existing approaches and develop novel study designs and methods to address problems arising from SPORE projects, where appropriate statistical methods are inadequate. SPORE biostatisticians have been closely involved with the projects in the SPORE. They will continue to collaborate as co-investigators on each project to ensure that studies are well designed and appropriately analyzed and interpreted. Moreover, the Core will provide consulting services to SPORE investigators for projects under the Research Developmental Program and the Career Development Program. The Core investigators have diverse and complementary expertise, and can conduct analyses using data from a wide variety of experimental technologies. For some of these technologies, analytic methods are still evolving. Core investigators are part of Consortium biostatistical research groups that are leaders in the areas of biomarker development, computational biology, and bioinformatics. In summary, the Core is well equipped to meet the diverse needs and address the translational aims of the Breast SPORE.