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中文摘要
翻译
分枝D.安德森癌症中心行政核心设施将作为该SPORE的联系点, 多发性骨髓瘤,因为后者努力开发新的方法来预防,早期发现, 诊断,分期和治疗这种血液恶性肿瘤。本核心的总体目标是提供 协调和监督SPORE活动,以促进内部和外部合作, 内部和外部的沟通,从而加快在一切可能的方式翻译 孢子的使命。该核心的具体目标将包括:1.为了保证整体科学质量, 所有SPORE组件的功能,包括五个项目、六个核心和开发 研究和职业发展计划; 2。建立并监控SPORE活动的合规性 符合所有适用的地方、州、国家和国际法规和要求; 3.监督 SPORE支出,并定期维护和分发预算信息; 4.组织和 召开所有必要的SPORE会议,包括内部和外部咨询委员会会议, 利用M. D.安德森会议和视频会议能力,并提供其摘要, 适用人员; 5.协助SPORE发展研究计划和职业发展 项目主任和联合主任管理这些重要组成部分; 6.支持编写 所有SPORE出版物和其他外部通信; 7.协调、获取和维护 参与中心对SPORE的机构承诺; 8.鼓励和促进内部和 SPORE间的通信、协作以及数据和资源共享;以及9.促进 与学术界和工业界的其他SPORE合作伙伴进行沟通和合作。通过 在这些活动中,行政核心将帮助既定项目和发展项目明确重点 他们的翻译目标,并确定和实施所需的步骤,将研究转化为和 从临床中产生改善多发性骨髓瘤临床相关终点的客观证据。
英文摘要
The M. D. Anderson Cancer Center Administrative Core Facility will serve as a nexus for this SPORE in Multiple Myeloma as the latter strives to develop novel approaches to the prevention, early detection, diagnosis, staging, and treatment of this hematologic malignancy. This Core's overall goals will be to provide coordination and oversight of SPORE activities, to facilitate internal and external collaborations as well as intramural and extramural communications, and to thereby expedite in every way possible the translational mission ofthe SPORE. Specific aims of this Core will include: 1. To assure the overall scientific quality and function of all of the SPORE components, including the five Projects, six Cores, and the Developmental Research and Career Development Programs; 2. To establish and monitor compliance of SPORE activities with all applicable local, state, national, and international regulations and requirements; 3. To oversee SPORE expenditures, and maintain and distribute budget information on a regular basis; 4. To organize and convene all necessary SPORE meetings, including those ofthe Internal and External Advisory Boards, utilizing the M. D. Anderson conference and videoconference capabilities, and provide summaries thereof to applicable personnel; 5. To assist the SPORE Developmental Research Program and Career Development Program Directors and Co-Directors in administering these vital components; 6. To support the preparation of all SPORE publications and other external communications; 7. To coordinate, obtain, and maintain Institutional commitments to the SPORE from the participating centers; 8. To encourage and facilitate intraand inter-SPORE communications, collaborations, and data and resource sharing; and 9. To promote communications and collaborations with other SPORE partners in both academia and industry. Through these activities, the Administrative Core will help both established and developmental projects clearly focus on their translational goals, and to identify and implement steps required to translate the research to and from the clinic to produce objective evidence of improving clinically relevant endpoints in multiple myeloma.
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Proteasome Assembly Chaperones in Sensitivity and Resistance to Proteasome Inhibitors
Proteasome Assembly Chaperones in Sensitivity and Resistance to Proteasome Inhibitors
P3 - TARGETING THE HDM-2 E3 LIGASE IN MULTIPLE MYELOMA
M. D. Anderson Cancer Center SPORE in Multiple Myeloma
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