FAMILIAL AND BIRTH COHORT EFFECTS ON THE AGING SENSES

描述(由首席研究员提供)：这项流行病学研究的目的是确定Beaver Dam子孙研究(BOSS)队列中听力、视力和嗅觉障碍、感觉并存和年龄相关性黄斑变性的5年发病率，潜在危险因素与这些感觉障碍和眼睛疾病的关系，风险的代际差异，并确定听力障碍的遗传标记。受试者是BOSS的参与者，在基线检查(2005-2008年)中年龄在21-84岁之间。拟议的检查将使用基线检查中使用的相同标准化方案，并将包括听力评估(耳镜、筛查鼓室导纳、测听、单词识别和双耳听力测试、失真产品耳声发射)、眼睛检查(屈光、视力测量、对比敏感度以及晶状体和视网膜的数字图像)、嗅觉测试(圣地亚哥气味识别测试)和血管测量(内中膜厚度、血压、视网膜小动脉和小静脉口径以及脉搏波速度)。将完成关于病史、生活方式因素和用药情况的标准化问卷。将在储存的基线样本上测量炎症标志物(VCAM-1、TNF-1、hsCRP)，以确定它们与感觉损伤发生率的关系。在听力损失流行病学研究(AG11099)中看到的来自老板和父母队列中年龄在45-79岁的成年人的存储样本，将使用50,000个心血管疾病、炎症和糖尿病候选基因的SNP小组进行基因分型。这项针对中年人的研究将提供重要的新信息，即婴儿潮时期(1946年-)出生的人与早期出生的人相比，感觉障碍的流行病学情况。我们认为，这些感觉障碍共享共同的潜在风险因素，这些因素可能通过炎症和血管途径发挥作用。这项研究将有助于开发针对中年的干预措施，以预防或推迟这些老龄化感官障碍的发生，并为规划满足婴儿潮一代老龄化的卫生保健需求提供必要的信息。公共卫生相关性：拟议的研究将为中年人患听力、嗅觉和视力障碍以及老年性黄斑变性的风险提供重要信息。了解与这些疾病发展相关的因素可能会导致新的治疗方法，旨在改善明天老年人的健康。

DESCRIPTION (provided by principal investigator): The purpose of this epidemiologic study is to determine the 5-year incidence of hearing, vision, and olfactory impairments, sensory co-morbidity and age-related macular degeneration in the Beaver Dam Offspring Study (BOSS) cohort, the associations of potential risk factors with these sensory impairments and ocular disorders, generational differences in risk and identify genetic markers for hearing impairment. Subjects are participants in the BOSS and were 21-84 years of age at the baseline examination (2005-2008). The proposed examination will use the same standardized protocols used in the baseline examination and will include a hearing evaluation (otoscopy, screening tympanometry, audiometry, word recognition and dichotic listening tests, distortion product otoacoustic emissions), eye examination (refraction, visual acuity measures, contrast sensitivity, and digital images of the lens and retina), olfaction testing (San Diego Odor Identification Test), and vascular measures (intima-medial thickness, blood pressure, retinal arteriolar and venular calibers, and pulse wave velocity). A standardized questionnaire about medical history, life-style factors and medication usage will be completed. Inflammatory markers (VCAM-1, TNF-1, hsCRP) will be measured on stored baseline samples to determine their associations with the incidence of sensory impairments. Stored samples from adults, ages 45-79 yrs in the BOSS and the parent cohort seen in the Epidemiology of Hearing Loss Study (AG11099), will be genotyped using a 50,000 SNP panel of candidate genes for cardiovascular disease, inflammation and diabetes. This study of middle-aged adults will provide important new information about the epidemiology of sensory impairments in the people born during the baby-boom period (1946-64) compared to people born in earlier periods. We propose that these sensory impairments share common underlying risk factors which may operate through inflammatory and vascular pathways. This study will contribute to developing interventions targeted at mid-life to prevent or delay the onset of these sensory disorders of aging and essential information for planning to meet the health care needs of the aging baby-boom generation. PUBLIC HEALTH RELEVANCE: The proposed study will contribute important information about the risk of developing hearing, olfaction and vision impairments and age-related macular degeneration in middle-aged adults. Understanding factors associated with the development of these conditions could lead to new treatments targeted at improving health for tomorrow's elders.