Epidemiologic Study of the Late Reproductive Years

这是一项关于卵巢老化的前瞻性队列研究的继续。这项研究的重点是激素 绝经前妇女进入和通过月经周期的动力学和相关症状 过渡到更年期。具体目的是：1)比较荷尔蒙水平和纵向趋势 非裔美国人和高加索女性之间的差异；2)确定这项研究的女性内部趋势 激素(雌二醇、卵泡刺激素、促黄体生成素、抑制素B、脱氢表雄酮和睾酮)和辅助因素，如体重指数、种族、年龄、 症状等预测过渡过程中的进展；3)确定激素动力学的关联 随着卵巢老化而出现的身体和行为症状，并确定这些人的种族差异 因素；4)确定遗传多态与水平和纵向趋势以及与 更年期症状。荷尔蒙评估和一系列身体和行为评估 每年在连续两个月经周期的第1-6天收集，或在不骑自行车的妇女相隔1个月收集。 这项队列研究的继续将提供有关激素动态及其对 在整个更年期过渡过程中出现的更年期症状。 超过80%的美国女性在更年期前后会出现身体或行为症状， 不同程度的严重程度和功能障碍，其中许多妇女寻求医疗救济 治疗令人痛苦的症状。对导致这些症状的因素及其原因缺乏了解 卵巢老化与激素因素的关系是一个重要的卫生保健问题。增加了 了解与生殖老化相关的变化以及是否存在种族差异 这些变化将导致更好的预防和治疗战略，以减少短期和长期 妇女中年和绝经后耳部发病率。

This is a continuation of a prospective cohort study of ovarian aging. The study focuses on hormone dynamics and associated symptoms as premenopausalwomen enter and move through stages in the transition to menopause. The specific aims are to: 1)) Compare hormone levels and longitudinal trends between African American and Caucasian women; 2) Identify how within-woman trends of the study hormones (estradiol, FSH, LH, Inhibin B, DHEAS, and testosterone) and cofactors such as BMI, race, age, symptoms, et al predict the progression through the transition; 3) Identify associations of hormonedynamics with physical and behavioral symptoms that occur with ovarian aging and identify racial differences in these factors; 4) Identify associations of genetic polymorphisms with levels and longitudinal trends and with menopausal symptoms. Hormone evaluations and a battery of physical and behavioral assessmentsare collected annually on days 1-6 of two consecutive menstrual cycles or 1 month apart in non-cycling women. Continuation of this cohort study will provide new information on hormone dynamics and their influences on menopausal symptoms through the full menopausal transition.- ¿¿¿¿ ......... More than 80% of U.S. women experience physical or behavioral symptoms around menopause,with varying degrees of severity and disruption in their functioning, and many of these women seek medical relief for distressing symptoms. The lack of understanding of the contributors to these symptoms and their associations with hormonal factors of ovarian aging is a significant health care problem. Increased understanding of the changes associated with reproductive aging and whether there are racial differences in these changes will lead to better preventive and therapeutic strategies to reduce the short and long term morbidity of women's mid-life and postmenopausalyears.