DEVELOPMENT OF SOFTWARE FOR IMAGE ANALYSIS, DISPLAY, AND MODELING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们继续开发和支持用于断层重建和图像显示、建模和分析的IMOD软件包。主要的里程碑是用于断层图像生成的eTomo图形界面的第一个版本(在别处描述)，以及用于Microsoft Windows和Macintosh OS X操作系统的全功能版本的发布。在过去的一年里增加了一些重要的功能，包括一个自动从ccd相机图像中移除X射线的程序，在将图像加载到3dmod显示和建模程序中时将其装入仓库的能力，以及为便于处理非常大的数据集而进行的其他更改。我们开发了一种新的方法，用于向程序提供参数输入，使其更容易手动运行或从eTomo等其他程序运行，允许在不破坏现有代码和命令文件的情况下向程序添加新的选项，并集中说明和记录程序选项。大约有15个Fortran程序已转换为新方法。文件方面也有重大改进：修订并大大扩充了3dmod指南，以全面介绍该程序；彻底修订了断层扫描指南，以描述如何使用eTomo；还发布了构建断层图像的指南以及完整的双轴数据集。随着新平台版本的发布，该软件的下载量比以往任何时候都要高。在2003年11月主要版本发布后的两周内，以及2003年2月/3月的7周内，从299个不同的IP地址进行了下载，其中49%用于Windows，25%用于Linux，21%用于Macintosh，5%用于SGI。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have continued development and support of the IMOD software package for tomographic reconstruction and image display, modeling, and analysis. Major milestones were the first release of the eTomo graphical interface for tomogram generation (described elsewhere) and the release of fully functional versions for Microsoft Windows and Macintosh OS X operating systems. Some significant functionality was added in the past year, including a program for automatic removal of X-rays from CCD camera images, the ability to bin down images when loading them into the 3dmod display and modeling program, and other changes to facilitate working with very large data sets. We developed a new method for providing parameter input to programs, to make it easier to run them manually or from other programs such as eTomo, to allow new options to be added to programs without breaking existing code and command files, and to centralize the specification and documentation of program options. About 15 Fortran programs have been converted to the new method. There were also major improvements in documentation: a guide to 3dmod was revised and greatly expanded to provide a comprehensive introduction to the program; a guide to tomography was thoroughly revised to describe how to work through eTomo; and a tutorial for building tomograms was also released, together with a complete dual-axis data set. With the release of versions for new platforms, downloads of the software are higher than ever. For the 2 weeks after the major version release in November 2003 plus 7 weeks in February/March 2003, there were downloads from 299 distinct IP addresses, of which 49% were for Windows, 25% for Linux, 21% for Macintosh, and 5% for SGI.