Genetic Network Linking Immunity to Energetic Stress, Metabolism and Reproduction

项目总监/首席调查员(最后、第一、中间)：Lazzaro，Brian P.1R01 AI083932-01 将免疫与能量应激、新陈代谢和生殖联系起来的遗传网络 摘要 对感染的抵抗力取决于免疫系统的活动和整体 寄主的生理状况。这个项目将决定看似 免疫、新陈代谢和生殖等不同的生理过程 在遗传模型系统中确定对感染的抵抗力的基因关联 黑腹果蝇。虽然果蝇是一种昆虫，但它的免疫和代谢 过程与脊椎动物的过程非常相似，以至于它可以作为 人类临床生物学的信息模型。果蝇也是一个重要的模型 其他昆虫，包括农业害虫和病媒

Program Director/Principal Investigator (Last, First, Middle): Lazzaro, Brian P. 1R01 AI083932-01 GENETIC NETWORK LINKING IMMUNITY TO ENERGETIC STRESS, METABOLISM, AND REPRODUCTION ABSTRACT Resistance to infection is determined by immune system activity and the overall physiological condition of the host. This project will determine how the seemingly disparate physiological processes of immunity, metabolism and reproduction are genetically linked to determine resistance to infection in the genetic model system Drosophila melanogaster. Although Drosophila is an insect, its immune and metabolic processes are sufficiently similar to those of vertebrates that it can serve as an informative model for human clinical biology. Drosophila is also an important model for other insects, including agricultural pests and disease vectors of