CALCIUM SIGNALING AND PREFRONTAL DEFICITS IN SCHIZOPHRENIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是耶鲁大学孔特中心基金的分包合同。在此期间，我们利用免疫电子显微镜和本实验室发展的定量分析方法，研究了正常猴前额叶皮质和各中间神经元亚群中D1家族多巴胺受体(D1和D5)和信号转导蛋白的分布。 我们验证了这样的假设，即对内源性配体多巴胺亲和力不同的D1和D5受体的不同分布，在D1家族多巴胺受体刺激与前额叶功能之间的倒U型关系中发挥了作用。 这些研究为我们了解多巴胺如何控制灵长类动物的认知，以及这种控制如何在精神分裂症中紊乱提供了基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is a subcontract of a Conte Center grant based at Yale University. During the reporting period, we used immunoelectron microscopy and quantitative analyses developed in our laboratory to study the distribution of D1 family dopamine receptors (D1 and D5) and signal transduction proteins in normal monkey prefrontal cortex as well as in various interneuron subpopulations. We tested the hypothesis that differential distribution of D1 and D5, receptors that differ in their affinity for the endogenous ligand dopamine, play a role in the inverted U curve relationship between D1 family dopamine receptor stimulation and prefrontal functioning. These studies provided us with a basis for understanding how dopamine controls cognition in primates and how this control might be disordered in schizophrenia.