Natural History of AIDS Homosexual Men

参见说明）： 加州大学洛杉矶分校的网站有25年的历史，作为MACS的临床网站的出色表现， 保持1637名参与者中88.5%以上的当前状态信息。善解人意， 他们中的大多数已经参与这项研究超过15年（有些已经25年 多年来），已被与会者引用为他们继续致力于加州大学洛杉矶分校MACS的关键。 实施了最先进的实验室程序，并实施了质量保证程序 地方该中心已经招募了一批杰出的加州大学洛杉矶分校的调查人员参加MACS， 并在各个科学领域发挥领导作用，领导发表了52篇研究论文 自2003年以来，为60篇其他MACS科学论文做出了贡献。 UCLA MACS临床中心的目标是： 1)保留1984 - 1985年招募的男子和2002 - 2003年招募的男子（主要是 西班牙裔美国人和非洲裔美国人）; 2)收集具体的行为，临床和心理社会数据，并从男性实验室标本; 3)处理实验室标本，用于当地和国家血清、血浆和 细胞，并对来自洛杉矶的这些样本进行流式细胞术和血清学测量 参与者; 4)维护本地存储库，供本地研究者使用; 5)为正在进行和未来的心血管并发症、肾功能、肝脏疾病的研究做出贡献， MACS参与者的神经认知障碍、恶性肿瘤、衰老和基因组特征; 6)通过领导多个MACS工作组（核心），为MACS提供科学领导 实验室、肿瘤/病理学、神经心理学），质量控制程序的组织， 领导主要的MACS文件和参与其他文件，并积极参与双月刊 MACS的电话会议和会议; 7)招募有经验的和新的研究人员，他们带来新的科学见解和技能， 提高MACS科学的质量和广度。 相关性（参见说明）： MACS包含了一个大型的信息数据库和每六个月收集一次的生物标本 从1984 - 1985年（主要是欧洲裔美国人）和2002 - 2003年（主要是拉丁裔和 非洲裔美国人），并允许继续观察3243名幸存者。因此，MACS提供了 不可替代的资源，用于继续研究治疗和未治疗的艾滋病毒感染的自然史， 艾滋病

See instructions): The UCLA site has a 25-year history of outstanding performance as a clinical site of the MACS, maintaining current status information on over 88.5% of the 1637 participants. The empathetic, committed staff, most of whom have been with the study for more than 15 years (and some for 25 years), has been cited by participants as a key to their continued commitment to the UCLA MACS. State-of-the-art laboratory procedures have been implemented, and quality assurance procedures put in place. The Center has recruited an outstanding group of UCLA investigators to participate in the MACS, and to assume leadership roles in various scientific areas, taking leadership for 52 research publications since 2003 and contributing to 60 other MACS scientific papers. The objectives of the UCLA MACS Clinical Center are to: 1) Maintain the cohorts of men recruited in 1984-5 and the men more recently recruited in 2002-3 (primarily Hispanic-Americans and African-Americans); 2) Collect specific behavioral, clinical and psychosocial data, and laboratory specimens from the men; 3) Process laboratory specimens for the local and national specimen repositories of serum, plasma, and cells and to perform flow cytometry and serologic measurements on these samples from Los Angeles participants; 4) Maintain the local repository for use by local investigators; 5) Contribute to ongoing and future studies of cardiovascular complications, renal function, liver diseases, neurocognitive impairment, malignancies, aging, and genomic characteristics of MACS participants; 6) Contribute scientific leadership to the MACS through leadership of several MACS working groups (Core Laboratory, Malignancies/Pathology, Neuropsychology),organization of quality control procedures, leadership in key MACS papers and participation in others, and active participation in the bi-monthly conference calls and meetings of the MACS; 7) Recruit both experienced and new investigators who bring new scientific insights and skills that will enhance the quality and breadth of science in the MACS. RELEVANCE (Seeinstructions): The MACS incorporates a large database of information and biologic specimens collected every six months from 6,972 men followed since 1984-5 (primarily European-American) and 2002-3 (primarily Latino and Africa-American), and allows continuing observation of the 3243 survivors. Thus, the MACS provides an irreplaceable resourcefor continued study of the natural history of treated and untreated HIV infection and AIDS.