MWCCS Covid-19 Supplement Activities
MWCCS Covid-19 补充活动
基本信息
- 批准号:10226756
- 负责人:
- 金额:$ 11.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAdmission activityAdult Respiratory Distress SyndromeAffectAfrican AmericanAgeAgingAllelesAngiotensin-Converting Enzyme InhibitorsAnti-Retroviral AgentsAntiviral AgentsAnxietyAppointmentAreaAzithromycinBiological MarkersBloodBody CompositionCOVID-19COVID-19 pandemicCardiacCardiomyopathiesCardiovascular systemCaringCessation of lifeChloroquineChronic lung diseaseClinicalCoagulation ProcessCohort StudiesCongestive Heart FailureDataDevelopmentDiabetes MellitusDiseaseDisease OutbreaksDisease OutcomeEpidemicEstrogensEthnic OriginExposure toFibrinogenFutureGeneticGenetic RiskGenotypeGeographic LocationsGeographyGoalsGuide preventionHIVHIV InfectionsHIV SeronegativityHIV SeropositivityHealthHealthcareHeart DiseasesHepatitis B VirusHepatitis C virusHigh PrevalenceHospitalizationHydroxychloroquineHypertensionImmuneImpairmentIncidenceIndividualInfectionInflammationIntegration Host FactorsIntensive Care UnitsInterruptionKidneyKnowledgeLopinavir/RitonavirLungMeasuresMechanical ventilationMental DepressionMorbidity - disease rateNational Heart, Lung, and Blood InstituteNeurocognitiveNeurologicObesityOrganOutcomeParticipantPatientsPersonal SatisfactionPhysical FunctionPopulationPoverty AreasRaceRecommendationRecoveryReportingResearchRespiratory physiologyRibavirinRiskRisk FactorsRunningSevere Acute Respiratory SyndromeSeveritiesSeverity of illnessSmokingSocial supportSpecimenSpirometrySurvivorsSymptomsSystemTimeViralVulnerable PopulationsWomanapolipoprotein E-4biobankcerebrovascularclinical predictorsco-infectioncohortcomorbiditycoronavirus diseaseethnic diversityexperiencegenetic risk factorgenome wide association studyhealth care availabilityhealth differenceimmune activationimprovedmenmetropolitanmortalitypandemic diseaseracial and ethnicracial disparityremdesivirrespiratoryresponsesexsocial factorstherapy development
项目摘要
ABSTRACT
COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12
million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild,
moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other
organ and blood systems. Studies document more severe disease and higher mortality among people who are
older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However,
there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV
(PWH). There is also little data to guide prevention and treatment recommendations for this population, many
of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also
the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial
racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS-
WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and
women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge
gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and
racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression
to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich
biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney,
neurocognitive, and physical function, body composition and has performed cohort-wide genome association
studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among
US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease
acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short-
term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and
geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.
摘要
新冠肺炎病例持续上升,美国有300多万例,13万人死亡,近12人死亡
到目前为止,全球有100万例病例。SARS CoV-2感染的表现从无症状到轻微,
中度或严重疾病,主要影响肺部,但越来越多的数据表明参与了其他
器官和血液系统。研究记录了更严重的疾病和更高的死亡率
年龄较大和/或患有高血压、糖尿病、肥胖症和慢性肺部疾病等并存疾病。然而,
关于艾滋病毒携带者感染的获得、发生和严重程度的数据很少。
(威尔斯亲王医院)。也几乎没有数据来指导这一人群的预防和治疗建议,许多人
其中一些人年龄较大,并患有可能不仅增加他们感染风险的合并症,而且
感染者的发病率和死亡率。此外,早期的报告显示,
美国新冠肺炎发病率的种族差异,非裔美国人死亡率的增加。Mac-
WIHS联合队列研究(MWCCS),最大和运行时间最长的男性和
美国艾滋病毒携带者或高危女性提供了一个独特的机会来解决重要的知识
在新冠肺炎的获得、发生、严重程度和结果方面存在差距。MWCCS是一个地理上和
种族/民族多样化的老年男性和女性,其进展的风险因素患病率很高
到严重的新冠肺炎疾病,包括高血压、糖尿病、肥胖和吸烟。MWCCS拥有丰富的
标本生物库,收集严格的临床措施,包括肺、心脏、肾脏、
神经认知和身体功能,身体组成,并进行了队列范围的基因组关联
学习。这个应用程序的首要目标是了解新冠肺炎疫情对
美国男性和女性感染艾滋病毒或有感染艾滋病毒的风险,并评估导致疾病的宿主因素
获得、表达、严重程度和恢复。拟议的研究将确定COVID的发病率,短期内-
长期和长期的临床结果,包括血栓形成和肺部后遗症,以及种族和
地理差异;免疫和遗传风险因素影响MWCCS的这些结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roger Detels其他文献
Roger Detels的其他文献
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{{ truncateString('Roger Detels', 18)}}的其他基金
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
9915992 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort Study
MACS-WIHS 联合队列研究中中老年男性和女性的听力和平衡研究
- 批准号:
10226754 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
10612795 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Innovation Fund Application to the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study (MWCCS): Covide-19 vaccine Acceptance & Hesitancy (CVBH) Study in People with HIV.
多中心艾滋病队列研究/妇女机构间艾滋病毒研究联合队列研究 (MWCCS) 创新基金申请:Covide-19 疫苗接受情况
- 批准号:
10397365 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
10400650 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
- 批准号:
9044842 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
9267557 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
9056890 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
8710843 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
- 批准号:
9266511 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
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