MWCCS Covid-19 Supplement Activities

摘要 新冠肺炎病例持续上升，美国有300多万例，13万人死亡，近12人死亡 到目前为止，全球有100万例病例。SARS CoV-2感染的表现从无症状到轻微， 中度或严重疾病，主要影响肺部，但越来越多的数据表明参与了其他 器官和血液系统。研究记录了更严重的疾病和更高的死亡率 年龄较大和/或患有高血压、糖尿病、肥胖症和慢性肺部疾病等并存疾病。然而， 关于艾滋病毒携带者感染的获得、发生和严重程度的数据很少。 (威尔斯亲王医院)。也几乎没有数据来指导这一人群的预防和治疗建议，许多人 其中一些人年龄较大，并患有可能不仅增加他们感染风险的合并症，而且 感染者的发病率和死亡率。此外，早期的报告显示， 美国新冠肺炎发病率的种族差异，非裔美国人死亡率的增加。Mac- WIHS联合队列研究(MWCCS)，最大和运行时间最长的男性和 美国艾滋病毒携带者或高危女性提供了一个独特的机会来解决重要的知识 在新冠肺炎的获得、发生、严重程度和结果方面存在差距。MWCCS是一个地理上和 种族/民族多样化的老年男性和女性，其进展的风险因素患病率很高 到严重的新冠肺炎疾病，包括高血压、糖尿病、肥胖和吸烟。MWCCS拥有丰富的 标本生物库，收集严格的临床措施，包括肺、心脏、肾脏、 神经认知和身体功能，身体组成，并进行了队列范围的基因组关联 学习。这个应用程序的首要目标是了解新冠肺炎疫情对 美国男性和女性感染艾滋病毒或有感染艾滋病毒的风险，并评估导致疾病的宿主因素 获得、表达、严重程度和恢复。拟议的研究将确定COVID的发病率，短期内- 长期和长期的临床结果，包括血栓形成和肺部后遗症，以及种族和 地理差异；免疫和遗传风险因素影响MWCCS的这些结果。

ABSTRACT COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12 million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild, moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other organ and blood systems. Studies document more severe disease and higher mortality among people who are older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However, there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV (PWH). There is also little data to guide prevention and treatment recommendations for this population, many of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS- WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney, neurocognitive, and physical function, body composition and has performed cohort-wide genome association studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short- term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.