MWCCS Covid-19 Supplement Activities
MWCCS Covid-19 补充活动
基本信息
- 批准号:10226756
- 负责人:
- 金额:$ 11.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAddressAdmission activityAdult Respiratory Distress SyndromeAffectAfrican AmericanAgeAgingAllelesAngiotensin-Converting Enzyme InhibitorsAnti-Retroviral AgentsAntiviral AgentsAnxietyAppointmentAreaAzithromycinBiological MarkersBloodBody CompositionCOVID-19COVID-19 pandemicCardiacCardiomyopathiesCardiovascular systemCaringCessation of lifeChloroquineChronic lung diseaseClinicalCoagulation ProcessCohort StudiesCongestive Heart FailureDataDevelopmentDiabetes MellitusDiseaseDisease OutbreaksDisease OutcomeEpidemicEstrogensEthnic OriginExposure toFibrinogenFutureGeneticGenetic RiskGenotypeGeographic LocationsGeographyGoalsGuide preventionHIVHIV InfectionsHIV SeronegativityHIV SeropositivityHealthHealthcareHeart DiseasesHepatitis B VirusHepatitis C virusHigh PrevalenceHospitalizationHydroxychloroquineHypertensionImmuneImpairmentIncidenceIndividualInfectionInflammationIntegration Host FactorsIntensive Care UnitsInterruptionKidneyKnowledgeLopinavir/RitonavirLungMeasuresMechanical ventilationMental DepressionMorbidity - disease rateNational Heart, Lung, and Blood InstituteNeurocognitiveNeurologicObesityOrganOutcomeParticipantPatientsPersonal SatisfactionPhysical FunctionPopulationPoverty AreasRaceRecommendationRecoveryReportingResearchRespiratory physiologyRibavirinRiskRisk FactorsRunningSevere Acute Respiratory SyndromeSeveritiesSeverity of illnessSmokingSocial supportSpecimenSpirometrySurvivorsSymptomsSystemTimeViralVulnerable PopulationsWomanapolipoprotein E-4biobankcerebrovascularclinical predictorsco-infectioncohortcomorbiditycoronavirus diseaseethnic diversityexperiencegenetic risk factorgenome wide association studyhealth care availabilityhealth differenceimmune activationimprovedmenmetropolitanmortalitypandemic diseaseracial and ethnicracial disparityremdesivirrespiratoryresponsesexsocial factorstherapy development
项目摘要
ABSTRACT
COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12
million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild,
moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other
organ and blood systems. Studies document more severe disease and higher mortality among people who are
older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However,
there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV
(PWH). There is also little data to guide prevention and treatment recommendations for this population, many
of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also
the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial
racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS-
WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and
women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge
gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and
racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression
to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich
biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney,
neurocognitive, and physical function, body composition and has performed cohort-wide genome association
studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among
US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease
acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short-
term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and
geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.
摘要
COVID-19病例继续增加,美国有超过3,000,000例病例和130,000例死亡,
迄今为止,全球有100万例。SARS CoV-2感染的表现从无症状到轻微,
中度或重度疾病,主要影响肺部,但越来越多的数据表明其他疾病的参与。
器官和血液系统。研究表明,在患有糖尿病的人群中,
老年人和/或患有合并症,如高血压、糖尿病、肥胖症和慢性肺病。然而,在这方面,
关于艾滋病毒感染者感染的获得、发生和严重程度的数据很少
(威尔斯亲王医院)。也几乎没有数据来指导对这一人群的预防和治疗建议,许多
其中年龄较大,患有合并症,不仅可能增加他们获得感染的风险,
感染者的发病率和死亡率。此外,早期报告显示,
美国COVID-19发病率的种族差异,非洲裔美国人的死亡率增加。MACS-
WIHS联合队列研究(MWCCS)是一项规模最大、运行时间最长的男性和女性观察性队列研究,
在美国,感染艾滋病毒或有感染艾滋病毒风险的妇女提供了一个独特的机会,
COVID-19的获得、发生、严重程度和结果方面的差距。MWCCS是一个地理和
具有高进展风险因素患病率的不同种族/人种老年男性和女性队列
严重的COVID-19疾病,包括高血压、糖尿病、肥胖和吸烟。MWCCS拥有丰富的
标本的生物储存库,收集严格的临床措施,包括肺,心脏,肾脏,
神经认知,身体功能,身体组成,并进行了队列范围的基因组关联
问题研究该应用程序的首要目标是了解COVID-19疫情对
美国男性和女性艾滋病毒感染或感染风险,并评估导致疾病的宿主因素
获得、表达、严重性和恢复。拟议的研究将确定COVID发病率,短期内-
长期和长期临床结局,包括血栓形成和肺部后遗症,以及种族和
地理差异;免疫和遗传风险因素影响MWCCS的这些结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roger Detels其他文献
Roger Detels的其他文献
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{{ truncateString('Roger Detels', 18)}}的其他基金
Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort Study
MACS-WIHS 联合队列研究中中老年男性和女性的听力和平衡研究
- 批准号:
10226754 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
9915992 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
10612795 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Innovation Fund Application to the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study (MWCCS): Covide-19 vaccine Acceptance & Hesitancy (CVBH) Study in People with HIV.
多中心艾滋病队列研究/妇女机构间艾滋病毒研究联合队列研究 (MWCCS) 创新基金申请:Covide-19 疫苗接受情况
- 批准号:
10397365 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
- 批准号:
10400650 - 财政年份:2019
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
- 批准号:
9044842 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
9267557 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
9056890 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
- 批准号:
8710843 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
- 批准号:
9266511 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
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