MWCCS Covid-19 Supplement Activities

MWCCS Covid-19 补充活动

• 批准号: 10226756
• 负责人: Roger Detels
• 金额: $ 11.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10226756
• 关键词: 2019-nCoV; Address; Admission activity; Adult Respiratory Distress Syndrome; Affect; African American; Age; Aging; Alleles; Angiotensin-Converting Enzyme Inhibitors; Anti-Retroviral Agents; Antiviral Agents; Anxiety; Appointment; Area; Azithromycin; Biological Markers; Blood; Body Composition; COVID-19; COVID-19 pandemic; Cardiac; Cardiomyopathies; Cardiovascular system; Caring; Cessation of life; Chloroquine; Chronic lung disease; Clinical; Coagulation Process; Cohort Studies; Congestive Heart Failure; Data; Development; Diabetes Mellitus; Disease; Disease Outbreaks; Disease Outcome; Epidemic; Estrogens; Ethnic Origin; Exposure to; Fibrinogen; Future; Genetic; Genetic Risk; Genotype; Geographic Locations; Geography; Goals; Guide prevention; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Health; Healthcare; Heart Diseases; Hepatitis B Virus; Hepatitis C virus; High Prevalence; Hospitalization; Hydroxychloroquine; Hypertension; Immune; Impairment; Incidence; Individual; Infection; Inflammation; Integration Host Factors; Intensive Care Units; Interruption; Kidney; Knowledge; Lopinavir/Ritonavir; Lung; Measures; Mechanical ventilation; Mental Depression; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Neurocognitive; Neurologic; Obesity; Organ; Outcome; Participant; Patients; Personal Satisfaction; Physical Function; Population; Poverty Areas; Race; Recommendation; Recovery; Reporting; Research; Respiratory physiology; Ribavirin; Risk; Risk Factors; Running; Severe Acute Respiratory Syndrome; Severities; Severity of illness; Smoking; Social support; Specimen; Spirometry; Survivors; Symptoms; System; Time; Viral; Vulnerable Populations; Woman; apolipoprotein E-4; biobank; cerebrovascular; clinical predictors; co-infection; cohort; comorbidity; coronavirus disease; ethnic diversity; experience; genetic risk factor; genome wide association study; health care availability; health difference; immune activation; improved; men; metropolitan; mortality; pandemic disease; racial and ethnic; racial disparity; remdesivir; respiratory; response; sex; social factors; therapy development

ABSTRACT COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12 million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild, moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other organ and blood systems. Studies document more severe disease and higher mortality among people who are older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However, there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV (PWH). There is also little data to guide prevention and treatment recommendations for this population, many of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS- WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney, neurocognitive, and physical function, body composition and has performed cohort-wide genome association studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short- term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.

摘要 COVID-19病例继续增加，美国有超过3，000，000例病例和130，000例死亡， 迄今为止，全球有100万例。SARS CoV-2感染的表现从无症状到轻微， 中度或重度疾病，主要影响肺部，但越来越多的数据表明其他疾病的参与。 器官和血液系统。研究表明，在患有糖尿病的人群中， 老年人和/或患有合并症，如高血压、糖尿病、肥胖症和慢性肺病。然而，在这方面， 关于艾滋病毒感染者感染的获得、发生和严重程度的数据很少 （威尔斯亲王医院）。也几乎没有数据来指导对这一人群的预防和治疗建议，许多 其中年龄较大，患有合并症，不仅可能增加他们获得感染的风险， 感染者的发病率和死亡率。此外，早期报告显示， 美国COVID-19发病率的种族差异，非洲裔美国人的死亡率增加。MACS- WIHS联合队列研究（MWCCS）是一项规模最大、运行时间最长的男性和女性观察性队列研究， 在美国，感染艾滋病毒或有感染艾滋病毒风险的妇女提供了一个独特的机会， COVID-19的获得、发生、严重程度和结果方面的差距。MWCCS是一个地理和 具有高进展风险因素患病率的不同种族/人种老年男性和女性队列 严重的COVID-19疾病，包括高血压、糖尿病、肥胖和吸烟。MWCCS拥有丰富的 标本的生物储存库，收集严格的临床措施，包括肺，心脏，肾脏， 神经认知，身体功能，身体组成，并进行了队列范围的基因组关联 问题研究该应用程序的首要目标是了解COVID-19疫情对 美国男性和女性艾滋病毒感染或感染风险，并评估导致疾病的宿主因素 获得、表达、严重性和恢复。拟议的研究将确定COVID发病率，短期内- 长期和长期临床结局，包括血栓形成和肺部后遗症，以及种族和 地理差异;免疫和遗传风险因素影响MWCCS的这些结果。