MWCCS Covid-19 Supplement Activities

MWCCS Covid-19 补充活动

• 批准号: 10226756
• 负责人: Roger Detels
• 金额: $ 11.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10226756
• 关键词: 2019-nCoV; Address; Admission activity; Adult Respiratory Distress Syndrome; Affect; African American; Age; Aging; Alleles; Angiotensin-Converting Enzyme Inhibitors; Anti-Retroviral Agents; Antiviral Agents; Anxiety; Appointment; Area; Azithromycin; Biological Markers; Blood; Body Composition; COVID-19; COVID-19 pandemic; Cardiac; Cardiomyopathies; Cardiovascular system; Caring; Cessation of life; Chloroquine; Chronic lung disease; Clinical; Coagulation Process; Cohort Studies; Congestive Heart Failure; Data; Development; Diabetes Mellitus; Disease; Disease Outbreaks; Disease Outcome; Epidemic; Estrogens; Ethnic Origin; Exposure to; Fibrinogen; Future; Genetic; Genetic Risk; Genotype; Geographic Locations; Geography; Goals; Guide prevention; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Health; Healthcare; Heart Diseases; Hepatitis B Virus; Hepatitis C virus; High Prevalence; Hospitalization; Hydroxychloroquine; Hypertension; Immune; Impairment; Incidence; Individual; Infection; Inflammation; Integration Host Factors; Intensive Care Units; Interruption; Kidney; Knowledge; Lopinavir/Ritonavir; Lung; Measures; Mechanical ventilation; Mental Depression; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Neurocognitive; Neurologic; Obesity; Organ; Outcome; Participant; Patients; Personal Satisfaction; Physical Function; Population; Poverty Areas; Race; Recommendation; Recovery; Reporting; Research; Respiratory physiology; Ribavirin; Risk; Risk Factors; Running; Severe Acute Respiratory Syndrome; Severities; Severity of illness; Smoking; Social support; Specimen; Spirometry; Survivors; Symptoms; System; Time; Viral; Vulnerable Populations; Woman; apolipoprotein E-4; biobank; cerebrovascular; clinical predictors; co-infection; cohort; comorbidity; coronavirus disease; ethnic diversity; experience; genetic risk factor; genome wide association study; health care availability; health difference; immune activation; improved; men; metropolitan; mortality; pandemic disease; racial and ethnic; racial disparity; remdesivir; respiratory; response; sex; social factors; therapy development

ABSTRACT COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US and almost 12 million cases worldwide to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild, moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other organ and blood systems. Studies document more severe disease and higher mortality among people who are older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease. However, there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV (PWH). There is also little data to guide prevention and treatment recommendations for this population, many of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial racial disparities in US COVID-19 rates, with increases in mortality among African Americans. The MACS- WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney, neurocognitive, and physical function, body composition and has performed cohort-wide genome association studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short- term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.

摘要