NATURAL HISTORY OF AIDS STUDY (UCLA IRB#: 95-03-113-31) SUBSTUDY TITLE: EFFECT O

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将尝试验证Brochner-Mortenson公式[Brochner-Mortensen 1972]用于确定感染HIV的成年男性的GFR，并确定使用该公式的两个最合适的时间点和碘海醇的血浆清除量。随着方法的验证，这项研究的主要结果将是GFR的下降率，这是在大约3年的两个时间点评估的。这项研究的主要目标是确定HIV感染和治疗是否是MACS中登记的男性肾功能更快下降的风险因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will attempt to validate the Brochner-Mortenson formula [Brochner-Mortensen 1972] for determining the GFR in adult men with HIV infection and to define the two most appropriate time points for use of this formula with the plasma clearance of iohexol. With the method validated, the main outcome in this study will be the rate of decline in GFR, as assessed at two time points approximately 3 years apart. The primary goal of this study is to determine the whether HIV infection and treatments for it are risk factors for a more rapid decline in kidney function in men enrolled in the MACS.