NATURAL HISTORY OF AIDS STUDY (UCLA IRB#: 95-03-113-31) SUBSTUDY TITLE: EFFECT O

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们将尝试验证Brochner-Mortensen公式[Brochner-Mortensen 1972]用于确定HIV感染成年男性的GFR，并确定使用该公式测定碘海醇血浆清除率的两个最合适的时间点。通过验证该方法，本研究的主要结局将是GFR的下降率，在相隔约3年的两个时间点进行评估。本研究的主要目的是确定HIV感染和治疗是否是MACS男性患者肾功能更快下降的风险因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will attempt to validate the Brochner-Mortenson formula [Brochner-Mortensen 1972] for determining the GFR in adult men with HIV infection and to define the two most appropriate time points for use of this formula with the plasma clearance of iohexol. With the method validated, the main outcome in this study will be the rate of decline in GFR, as assessed at two time points approximately 3 years apart. The primary goal of this study is to determine the whether HIV infection and treatments for it are risk factors for a more rapid decline in kidney function in men enrolled in the MACS.