Study of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort Study

MACS-WIHS 联合队列研究中中老年男性和女性的听力和平衡研究

基本信息

  • 批准号:
    10226754
  • 负责人:
  • 金额:
    $ 5.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-15 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

Abstract According to the 2014 U.S. National Health Interview Survey, 5.5% of adults aged 18-39 years old self- reported trouble with hearing without a hearing aid. Among adults 40-69 years of age, the rate was 19% increasing to 43% among adults aged 70 and over with 63% reporting mild hearing loss. To date, there has been no published results from these survey data of people living with HIV (PLWH) due to lack of reported HIV status. In a pilot study of middle-aged and aging HIV positive and HIV seronegative men and women conducted in Washington DC and Baltimore, HIV infection was associated with low and high frequency hearing loss. But, more rigorous studies are needed, especially as more than half of PLWH in the U.S. are over the age of 50 years old. Besides age and race/ethnicity differences in hearing and balance, being overweight, increased alcohol consumption, smoking, less physical activity, the occurrence of hypertension and diabetes are common risk factors for hearing and balance problems. These risk factors may also be higher in PLWH and share a common hallmark of inflammation and immune activation. Furthermore, hearing and balance problems may contribute to neurocognitive and physical dysfunction, which are also of concern in aging PLWH. Finally, there is no research on the use of hearing testing applications in adults with HIV. Evaluation of the feasibility of using a hearing testing application and the accuracy of a smartphone hearing testing application in PLWH and their HIV seronegative counterparts are needed. We propose to address these gaps in knowledge by implementing cohort-wide administration of the NHANES hearing (and balance questionnaire) in the MACS-WIHS Combined Cohort Study (MWCCS) in approximately 4,100 active middle aged and aging men and women living with and without HIV. In a subset of participants from the Washington-DC and Baltimore sites with baseline hearing and balance data collected in 2009-2010 with follow-up testing in 2020-2021, we propose to investigate whether the trajectory of markers of immune activation and inflammation contribute to progression of hearing and balance issues, and whether a smartphone hearing test application may be a feasible method to capture hearing trouble in PLWH compared to HIV seronegative participants.
摘要

项目成果

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Roger Detels其他文献

Roger Detels的其他文献

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{{ truncateString('Roger Detels', 18)}}的其他基金

Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
  • 批准号:
    9915992
  • 财政年份:
    2019
  • 资助金额:
    $ 5.95万
  • 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
  • 批准号:
    10612795
  • 财政年份:
    2019
  • 资助金额:
    $ 5.95万
  • 项目类别:
Innovation Fund Application to the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study (MWCCS): Covide-19 vaccine Acceptance & Hesitancy (CVBH) Study in People with HIV.
多中心艾滋病队列研究/妇女机构间艾滋病毒研究联合队列研究 (MWCCS) 创新基金申请:Covide-19 疫苗接受情况
  • 批准号:
    10397365
  • 财政年份:
    2019
  • 资助金额:
    $ 5.95万
  • 项目类别:
Los Angeles CRS for the MACS/WIHS Combined Cohort Study
洛杉矶 CRS 的 MACS/WIHS 联合队列研究
  • 批准号:
    10400650
  • 财政年份:
    2019
  • 资助金额:
    $ 5.95万
  • 项目类别:
MWCCS Covid-19 Supplement Activities
MWCCS Covid-19 补充活动
  • 批准号:
    10226756
  • 财政年份:
    2019
  • 资助金额:
    $ 5.95万
  • 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
  • 批准号:
    9044842
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
  • 批准号:
    9267557
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
  • 批准号:
    9056890
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:
UCLA/Myanmar Training Program in Advanced HIV/AIDS Methodologies
加州大学洛杉矶分校/缅甸高级艾滋病毒/艾滋病方法培训计划
  • 批准号:
    8710843
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:
UCLA/Thai MoPH Epidemiology Training Program on AIDS
加州大学洛杉矶分校/泰国卫生部艾滋病流行病学培训项目
  • 批准号:
    9266511
  • 财政年份:
    2014
  • 资助金额:
    $ 5.95万
  • 项目类别:

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