Cancer Cell Biology

肿瘤细胞生物学 癌症细胞生物学计划的目标是促进跨越现代细胞生物学关键主题的综合研究，特别是与癌症病因学，预防和治疗有关的研究，通过建立或扩大适当的核心设施来提高成员的能力，并促进与其他CCLCCC基础，临床和人口科学计划的互动。方案研究是 组织围绕五个主要领域：血管生成和血管生物学，细胞粘附和细胞骨架，细胞周期，细胞信号，染色质调节和表观遗传学。节目亮点包括发现：张毅（被任命为霍华德休斯医学研究所的研究员，2004）的组蛋白脱甲基酶的JmjC结构域（JMJD）家族和脱甲基酶D 0 T1 L在白血病发生中的功能（Cell，2005）;饰Ted Salmon（当选为美国艺术与科学学院的成员，2006）的着丝粒的控制和架构{Cell，2005; Cell，2007; Cell，2009）; by Jim Bear（2009年被霍华德休斯医学研究所任命为早期职业科学家）控制肌动蛋白结构分支的新机制; Henrik Dohlman的新RGS通路组分; Bill Marzluff的组蛋白前mRNA加工的关键组分;岳雄提出了胶质瘤的发病机制--代谢酶1DH 1突变和代谢酶乙酰化。该项目由熊岳博士领导，熊岳博士是生物化学与生物物理学教授，自1993年以来一直是项目成员，自2006年以来一直是项目负责人。他以细胞周期控制、肿瘤抑制和泛素途径的研究而闻名。目前，该方案有47个成员，他们在2009年共筹集了3 510万美元的校外资金（总费用），其中包括610万美元的国家癌症研究所资金。从2004年到2009年，出版物总数为1，245份;其中10%为计划内出版物，10%为计划间出版物。该计划的未来计划包括在新领域的选择性招聘，并更加重视翻译研究和内部和跨程序的互动。

Cancer Cell Biology The goal of the Cancer Cell Biology Program is to foster integrated research that spans key themes of modern cell biology, especially as they relate to cancer etiology, prevenfion and therapy, to enhance the capabilities of members through establishment or expansion of appropriate core facilities, and to promote interactions with other UNC LCCC basic, clinical and population science programs. Program research is organized around five major areas: angiogenesis & vascular biology, cell adhesion & cytoskeleton, cell cycle, cell signaling, and chromatin regulafion & epigenetics. Program highlights include the discoveries: by Yi Zhang (appointed as an Investigator of Howard Hughes Medical Institute, 2004) of the JmjC domain (JMJD) family of histone demethylases and the function of demethylase D0T1L in in leukemogenesis {Cell, 2005); by Ted Salmon (elected a member of the American Academy of Arts and Sciences, 2006) of the control and architecture of the kinetochore {Cell, 2005; Cell, 2007; Cell, 2009); by Jim Bear (appointed as Early Career Scientist by the Howard Hughes Medical Institute, 2009) of new mechanims in the control of actin architecture branching; by Henrik Dohlman of new RGS pathway components; by Bill Marzluff the key components of histone pre-mRNA processing; and by Yue Xiong of the mechanism underlying glioma-mutation of metabolic enzyme 1DH1 and acetylation of metabolic enzymes by acetylation. The Program is led by Dr. Yue Xiong, professor of Biochemistry & Biophysics, a Program member since 1993 and Leader since 2006. He is known for his studies of cell cycle control, tumor suppression and the ubiquitin pathway. At present, the Program has 47 members who have generated a total of $35.1 M (total cost) in extramural funding in 2009, including $6.1 million of NCI funding. From 2004 to 2009, the total number of publications was 1,245; 10% of which were intra-programmatic and 10% were inter-programmatic. Future plans for the Program include selective recruitment in new areas, and increased emphasis on translational studies and intra- and inter-programmatic interactions.