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中文摘要
翻译
这个核心有两个相关的组件,它们提供不同的服务。CNS/PNS损伤核心将提供技术支持,以建立损伤的动物模型,并描述其损伤后的行为障碍。啮齿动物行为核心将提供服务,以标准行为范例测试啮齿动物模型。 该核心组件还与Genetics Core协同工作,并提供了一种机制来分析转基因和基因敲除小鼠的行为。 I.CNS/PSN神经损伤核心 概述 对CNS/PNS神经损伤的研究是俄亥俄州立大学校园的一大优势。有了这一核心提供的服务,NINDS资助的研究人员将能够通过轻松获得通常不在一个实验室中一起使用的一系列外科和行为技术来极大地扩大他们的工作范围。 该核心还将提供在CNS/PNS损伤模型中测试新型药物的能力。 在目前的奖项中,9个PIS使用了这个核心,从而产生了16篇论文和1个新的R01。
英文摘要
This Core has two related components that offer different services. The CNS/PNS Injury Core will provide technical support to generate animal models of Injury and to characterize their behavioral impairment after injury. The Rodent Behavior Core will provide services to test rodent models in standard behavioral paradigms. This Core component also synergizes with the Genetics Core and provides a mechanism to analyze the behavior of transgenic and knockout mice. I. CNS/PSN Nerve Injury Core Overview The study of CNS/PNS nerve Injury is a major strength on the OSU campus. With the services available in this Core, NINDS funded investigators will be able to greatly expand the scope of their work by having easy access to an array of surgical and behavioral techniques which are not typically located together in a single laboratory. This Core will also provide the ability to test novel agents in CNS/PNS Injury models. During the current award nine Pis used this Core resulting in sixteen papers and one new R01.
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Spinal cord injury causes liver pathology and metabolic dysfunction
  • 批准号:
    10589087
  • 项目类别:
  • 资助金额:
    $53.75万
  • 财政年份:
    2021
  • 负责人:
    DANA M MCTIGUE
  • 依托单位:
Spinal cord injury causes liver pathology and metabolic dysfunction
  • 批准号:
    10210615
  • 项目类别:
  • 资助金额:
    $53.99万
  • 财政年份:
    2021
  • 负责人:
    DANA M MCTIGUE
  • 依托单位:
Spinal cord injury causes liver pathology and metabolic dysfunction
  • 批准号:
    10377530
  • 项目类别:
  • 资助金额:
    $53.75万
  • 财政年份:
    2021
  • 负责人:
    DANA M MCTIGUE
  • 依托单位:
Regulation of myelination after spinal cord injury
  • 批准号:
    10187660
  • 项目类别:
  • 资助金额:
    $43.61万
  • 财政年份:
    2018
  • 负责人:
    DANA M MCTIGUE
  • 依托单位:
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