K24 Mid-Career Investigator Award in Eating and Weight Disorders

描述（由申请人提供）：本申请代表K24中期职业研究者奖在饮食和体重障碍患者为导向的研究的竞争性更新。Grilo博士正在寻求K24奖的续期，以减轻他的行政和临床职责，以确保有保护的时间继续：（1）专注于临床研究，以改善饮食/体重失调的治疗方法;（二）发展先进的研究技能，进一步提高他作为研究人员和导师的有效性，以积极影响下一代治疗方法和研究人员;和（3）指导博士后临床研究人员和初级教师在肥胖和饮食失调领域需要解决这些日益严重的重大公共卫生问题。在最初的资助期间，Grilo博士完成了三项随机对照试验，作为PI从NIH获得了两项R 01的新资金，并获得了一项基金会资助，用于在不同环境中为饮食失调的肥胖患者进行随机对照试验，并作为几项NIH赠款的共同研究者。在最初的K24期间，Grilo博士发表了110篇同行评审的研究论文，指导了20名学员或初级教师，指导了6项成功的NIH贷款偿还计划申请，并指导或共同指导了5项资助的K23职业发展奖。续约奖将使Grilo博士能够进一步增加他的综合研究和指导活动。在正在进行的研究中，将允许强化指导，包括一项随机对照试验，该试验测试了对患有暴食症的肥胖患者进行标准行为减肥治疗的阶梯式护理方法（R 01 DK 49587）和一项随机对照试验（RCT），通过自助和药物治疗单独和联合测试认知行为疗法，在全科初级保健机构中患有暴食症的肥胖患者中（R 01 DK 073542）。一个更新的奖项将允许Grilo博士在患有暴食症的肥胖患者中进行认知控制任务和奖励处理过程中神经激活的fMRI试验研究。续约也将使Grilo博士能够进一步提高他的科学能力，他已经获得了国际公认的专家顾问在肥胖，饮食失调，治疗方法，生物统计学和神经生物学研究方面的合作。Grilo博士的项目与其他临床研究和培训项目相结合（例如，CTSA）在耶鲁大学，共同提供了充足的机会和资源。Grilo博士将继续支持和促进博士后和初级教师临床研究人员在饮食/体重障碍方面的进步，通过强化指导，完成研究项目，发表研究报告，并成功获得职业发展（例如，K23）和研究补助金支持。 公共卫生相关性：该申请代表了K24中期职业研究者奖在饮食和体重障碍患者为导向的研究的竞争性更新。更新奖将为候选人提供高达50%的努力，在未来五年的每一年继续他的临床研究，重点是改善饮食/体重失调的治疗方法，并进一步扩大他的博士后和初级教师研究人员的指导需要解决这些日益增长的重大公共卫生问题。

DESCRIPTION (provided by applicant): This application represents a competitive renewal of a K24 Mid-Career Investigator Award in Patient-Oriented Research in Eating and Weight Disorders. Dr. Grilo is seeking a renewal of the K24 Award in order to relieve him from administrative and clinical duties to ensure protected time to continue to: (1) focus on clinical- research to improve treatment methods for eating/weight disorders; (2) develop advanced research skills needed to enhance further his effectiveness both as a researcher and as a mentor in order to positively impact the next generation of treatment methods and researchers; and (3) mentor postdoctoral clinical researchers and junior faculty in the area of obesity and disordered eating needed to address these growing major public health problems. During the initial funded period, Dr. Grilo completed three RCTs, obtained new funding as PI on two R01s from the NIH and a Foundation Grant to perform RCTs for obese patients with disordered eating in diverse settings, and as co-Investigator on several NIH grants. During the initial K24, Dr. Grilo published 110 peer-reviewed research papers, mentored 20 trainees or junior faculty, mentored six successful NIH Loan Repayment Program applications, and mentored or co-mentored five funded K23 Career Development Awards. A renewal award will allow Dr. Grilo to increase further his integrated research and mentoring activities. Among the on-going studies that will allow for intensive mentoring include a RCT testing a stepped care approach to a standard behavioral weight loss treatment for obese patients with binge eating disorder (R01 DK49587) and a RCT testing cognitive behavioral therapy via self-help and pharmacotherapy, alone and in combination, in obese patients with binge eating disorder in generalist primary care settings (R01 DK073542). A renewal award will allow Dr. Grilo to perform pilot fMRI investigations of neural activation during cognitive control tasks and reward processing in obese patients with binge eating disorder. A renewal award will also allow Dr. Grilo to advance further his scientific capabilities and he has secured the collaboration of internationally-recognized expert consultants in obesity, eating disorders, treatment methods, biostatistics, and neurobiological research. Dr. Grilo's program is integrated with other clinical-research and training programs (e.g., CTSA) at Yale which collectively offer ample opportunities and resources. Dr. Grilo will continue to support and facilitate the advancement of postdoctoral and junior faculty clinical-researchers in eating/weight disorders via intensive mentoring geared towards completing research projects, publishing studies, and successfully obtaining career development (e.g., K23) and research grant support. PUBLIC HEALTH RELEVANCE: This application represents a competitive renewal of a K24 Mid-Career Investigator Award in Patient-Oriented Research in Eating and Weight Disorders. The renewal award will provide the candidate up to 50% effort for each of the next five years to continue his clinical-research focused on improving treatment methods for eating/weight disorders and to expand further his mentoring of postdoctoral and junior faculty researchers needed to address these growing major public health problems.