Discovery of Chemical Probes and Therapeutic Leads

描述（由申请人提供）：在该COBRE中，开发化学探针和治疗引线的新方法将由不同的科学家团队进行。该COBRE将创建用于高通量筛选的新库，提供关于先天免疫应答和神经退行性疾病的新观点，实现新的筛选技术，并推进虚拟筛选的最新技术水平。拟议的COBRE将通过五个子项目在整个UD校园建立一个科学合作网络： 1.免疫刺激性小分子文库的建立 2.用于高通量药物筛选的体外神经疾病模型 3.制备多种小分子文库的新合成方法 4.用于快速化学探针识别的电化学化学发光阵列和发射体 5.实现高通量虚拟筛选的预测承诺 拟议的COBRE将在UD和Nemours儿童癌症研究中心的科学家之间建立一个区域生物医学合作网络。在所有五个子项目的丰富合作中，UD研究人员将与NCI的科学家进行广泛的交流 分子靶实验室（MTL）和化学生物学实验室（CBL），与NCI科学家的指导，NCI研究生的交叉训练经验，以及对有前途的发现进行后续跟踪的合作机制。 通过新的核心仪器和设施，COBRE将增加UD生物医学研究的基础设施。该中心的范围将通过教师招聘和种子赠款，并通过明确的机制，将促进生物和化学的后续行动的初步发现进一步扩大。该COBRE还将建立一个指导网络，支持助理教师的职业发展，并将他们置于加速独立资助的道路上。

DESCRIPTION (provided by applicant): In this COBRE, novel approaches to developing chemical probes and therapeutic leads will be pursued by a diverse team of scientists. This COBRE will create new libraries for high-throughput screening, provide new perspectives on innate immune response and neurodegenerative disease, enable new screening technology, and advance the state of the art in virtual screening. The proposed COBRE will build a network of scientific collaboration throughout the UD campus through five subprojects: 1. Development of an Immunostimulatory Small Molecule Library 2. In vitro neural disease models for high throughput drug screening 3. New Synthetic Methods for Diverse Small Molecule Library Preparation 4. Electrochemical Chemiluminescent Arrays and Emitters for Rapid Chemical Probe Identification 5. Realizing the predictive promise of high throughput virtual screening The proposed COBRE will establish a regional network of biomedical collaboration between scientists at UD and the Nemours Center for Childhood Cancer Research. In a rich collaboration across all five subprojects, UD researchers will interface extensively with scientists from the NCI Molecular Targets Laboratory (MTL) and Chemical Biology Laboratories (CBL), with interactions that include mentorship by NCI scientists, crosstraining experiences for graduate students at NCI, and collaborative mechanisms for follow-up on promising discoveries. With new core instrumentation and facilities, this COBRE will increase the infrastructure for biomedical research at UD. The scope of the center will be further expanded through faculty recruitment and seed grants, and via explicit mechanisms that will facilitate both biological and chemical follow-up on initial discoveries. This COBRE will also establish a mentoring network that will support the career development of assistant faculty, and place them on an accelerated path toward independent funding.