2014 Post-Transcriptional Gene Regulation Gordon Research Conference & Gordon Res

描述(由申请者提供)：2014年关于转录后基因调控的戈登研究会议(GRC)将是始于2004年的两年一次的系列会议中的第六次。今年的会议将于7月13日至18日在密苏里州纽波特的Salve Regina大学举行，并将于7月12日至13日举行戈登研究研讨会(GRS)。这一GRC和GRS提供了杰出的论坛，以展示和讨论关于正常和疾病状态下RNA代谢的调节和调节的新发现，以及如何针对和/或利用这些过程来治疗人类疾病。阐明转录后基因调控的基本机制对于全面了解现代基因组的组织、进化和功能，以及RNA代谢功能障碍在许多遗传和获得性疾病中的参与是至关重要的。这些基础知识支持基于或靶向特定转录后过程的新疗法的开发。今年会议的重点领域将包括RNA进化、RNA加工、编辑和核苷酸修饰、RNA-蛋白质(RNP)复合体的组装和动力学、细胞内和细胞外RNP的运输、mRNA的翻译和衰退、长和短非编码RNA的功能、RNA毒性、RNA代谢异常对先天性和神经退行性疾病的贡献，以及由于我们对转录后机制的理解不断加深而产生的新的治疗途径。2014年会议的一个关键目标是加强学术和工业科学家之间的互动，以实现他们的互惠互利，并促进新疗法的开发。考虑到这一点，今年的演讲者中有很大一部分来自这一快速发展的治疗领域的公司。GRC将召集大约45名演讲者，代表转录后基因调控和治疗开发的关键领域，总共有来自学术界和工业界的160-200名与会者。几个简短的演讲将从抽象的投稿中挑选出来。下午晚些时候的海报会议将使所有参与者能够对上述主题作出贡献并了解这些主题。四张最好的海报将被确认：两名研究生和两名博士后。所有参与者还将在用餐时间以及自由的下午早些时候和晚上进行互动。虽然科学的质量将是前沿的，但氛围的目标是放松和互动。对于早期研究人员，在GRC之前也将有为期两天的GRS；GRS将为这些年轻科学家提供一个机会，既磨练他们的演讲技能，又适应参加高水平的科学会议。对于有兴趣从事工业职业的研究生和博士后，GRS将包括与行业领袖和早期行业研究人员的小组讨论。

DESCRIPTION (provided by applicant): The 2014 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation will be the sixth in a biennial series that began in 2004. This year's meeting will be held July 13-18 at Salve Regina University in Newport, RI, and will be accompanied by a Gordon Research Seminar (GRS) on July 12-13. This GRC and GRS provide outstanding forums to present and discuss new findings about the mediation and regulation of RNA metabolism in normal and diseased states, and how such processes can be targeted and/or harnessed to treat human disease. Elucidating the basic mechanisms of post-transcriptional gene regulation is essential to fully understand the organization, evolution and function of present-day genomes, as well as the involvement of RNA metabolic dysfunction in numerous genetic and acquired disorders. Such fundamental knowledge underpins development of novel therapeutics based on or targeting specific post-transcriptional processes. Areas of emphasis at this year's meeting will include RNA evolution, RNA processing, editing and nucleotide modification, RNA-protein (RNP) complex assembly and dynamics, intra- and extra-cellular RNP transport, mRNA translation and decay, the functions of long and short non-coding RNAs, RNA toxicity, the contributions of abnormal RNA metabolism to congenital and neurodegenerative diseases, and novel therapeutic avenues arising from our ever-increasing understanding of post-transcriptional mechanisms. A key goal of the 2014 meeting is to increase interaction between academic and industrial scientists for their mutual benefit and to facilitate development of novel therapeutics. With this in mind, a significant proportion of this year's speakers come from companies working in this rapidly evolving therapeutic space. The GRC will convene approximately 45 speakers representing key areas of post-transcriptional gene regulation and therapeutic development, with a total of 160-200 participants from both academia and industry. Several short talks will be chosen from abstract submissions. Late afternoon poster sessions will enable all participants to contribute to and learn about the above-mentioned topics. Four top posters will be acknowledged: two graduate students' and two post-docs'. All participants will also interact at meal times and during free early afternoon and late evening periods. While the quality of science will be cutting-edge, the atmosphere is aimed at being relaxed and interactive. For early stage investigators, there will also be a two- day GRS immediately prior to the GRC; the GRS will provide an opportunity for these young scientists to both hone their speaking skills and to become comfortable participating in a high level scientific conference. For graduate students and postdocs interested in pursuing a career in industry, the GRS will include a panel discussion with industry leaders and early stage industry researchers.