Innate immunity in food allergy

项目总结 这份多元化副刊将支持贾斯汀·诺埃尔的职业发展，她将撰写博士论文 在塞西莉亚·贝林的指导下进行的研究。家长基金(U19基金AI136053，《免疫基础与临床》 基于阈值的花生过敏表型的含义“)将检查临床的免疫基础 花生过敏的异质性，重点是花生的适应性和效应性免疫反应。 在这份补充提案中，Noel女士将研究先天免疫，并重点研究髓系(单核细胞和树突状细胞 细胞)对亲本资助中描述的相同队列中的花生的反应。候选人的职业生涯 发展计划将包括强化口头和书面交流、赠款书写和技术技能培训 开发以细胞为基础的技术，以及计算免疫学的教学培训。 导师技能的发展也是职业发展计划的一个组成部分，并符合长期的 候选人的学期目标是与儿童合作，向少数族裔学生展示科学是有趣和有益的， 并激励来自各种背景的年轻人进入STEM领域。

PROJECT SUMMARY This Diversity Supplement will support the career development of Justine Noel who will perform PhD thesis studies under the mentorship of Cecilia Berin. The parent grant (U19 grant AI136053, “Immune Basis & Clinical Implications of Threshold-Based Phenotypes of Peanut Allergy”) will examine the immune basis of clinical heterogeneity of peanut allergy, with an emphasis on the adaptive and effector immune responses to peanut. In this supplement proposal, Ms. Noel will study innate immunity and focus on myeloid (monocyte and dendritic cell) responses to peanut within the same cohort described in the parent grant. The candidate career development plan will include intensive training in oral and written communication, grant writing, technical skill development with CyTOF-based technologies, and didactic training in computational immunology. Development of mentorship skills is also a component of the career development plan, and fits with the long- term goals of the candidate to work with children to show minority students that science is fun and rewarding, and stimulate young minds from all backgrounds to enter the STEM field.