BioMedical Big Data Core

项目摘要 这个拟议的COBRE中心的目标是将计算和基本生物学方法结合起来， 研究人类疾病。为了支持这一总体目标，拟议的生物医学大数据核心（BBD 核心）将为布朗和附属医院的生物医学研究人员建立必要的基础设施 获取、存储、处理和分析大规模生物医学数据集。近期的主要使命 BBD核心的目的是支持初级研究者分析和解释高通量 DNA/RNA测序数据集，包括实验室生成的数据和大规模测序数据。 可用的数据集。BBD核心将作为大数据分析的中心资源，并将解决 多个初级研究者共享的计算和分析需求，缺乏 资源，以建立必要的资源，在其研究小组。核心还将促进 COBRE中项目之间的科学互动，在以下共同主题之间协同作用： 生物医学大数据BBD核心的长期目标是提供可持续的资源， 布朗大学和我们的当代基因组学研究所面临的大数据挑战 附属医院。该资源将使生物医学研究人员能够专注于科学和 这些研究的临床挑战，同时也避免了不必要的冗余， 在每个实验室独立的计算/分析专业知识。核心还提供培训 为广大的研究界，以确保下一批初级研究人员的可持续性。 Benjamin Raphael博士和Zhijin Wu博士将担任BBD核心的教师领导。这一核心将 增加四名科学家，以促进人类疾病研究的计算方法。一 计算生物学家/总监将监督日常操作和资源分配。数据库 开发人员将与所有项目合作，开发和维护项目数据和公共数据库。 基因组数据库计算机程序员将开发用于数据处理的管道， 在主任和COBRE Junior的指导下实施现有和/或新的算法 Investigators.生物统计学家将提供数据分析支持。

PROJECT SUMMARY The goal of this proposed COBRE Center is to unite computational and basic biological approaches to the study of human disease. To support this general goal, the proposed Biomedical Big Data Core (BBD Core) will build the necessary infrastructure for biomedical researchers at Brown and Affiliated Hospitals to acquire, store, process, and analyze large-scale biomedical datasets. The near-term, primary mission of the BBD Core is to support Junior Investigators in the analysis and interpretation of high-throughput DNA/RNA sequencing datasets, including both data generated in their laboratories and large publically available datasets. The BBD Core will serve as the central resource for big data analysis, and will address the computational and analytical needs shared by multiple Junior Investigators, investigators who lack resources to build the necessary resources within their research groups. The Core will also facilitate scientific interactions between the projects in the COBRE, synergizing across common themes of biomedical big data. The long-term goal of the BBD Core is to provide a sustainable resource to support the big data challenges faced by contemporary genomics studies across Brown University and our Affiliated Hospitals. This resource will enable biomedical researchers to focus on the scientific and clinical challenges of such studies, while also avoiding unnecessary redundancy by building computational/analytical expertise independently in each laboratory. The Core also provides training for the broad research community to ensure the sustainability of next cohort of junior investigators. Dr. Benjamin Raphael and Dr. Zhijin Wu will be the faculty leaders of the BBD Core. This Core will add four staff scientists to facilitate computational approaches to human disease research. A Computational Biologist/Director will oversee routine operations and resources allocation. The database developer will work with all projects to develop and maintain databases of project data and public genomic databases. The computer programmer will develop pipelines for data processing and implement existing and/or novel algorithms under the guidance of the director and COBRE Junior Investigators. The Biostatistician will provide data analysis support.