Training in Cell Signaling and Lung Pathobiology

描述（由申请人提供）：本更新申请要求继续支持南亚拉巴马大学医学院肺部生物学中心的“细胞信号传导和肺部病理生物学”博士前/短期培训计划。由于我们的培训计划的博士前部分通过资金的第一个周期（2004-2009年）成熟，我们在第二个周期（2009-2014年）增加了短期培训，以支持夏季研究经验。鉴于我们在培训方面的成功，在这次更新申请中，我们要求继续支持博士前学员（6个名额）和短期暑期研究的医学生学员（4个名额）。培训的研究领域包括肺动脉高压中肺血管收缩和血管重塑的潜在机制，血管和气道平滑肌生物学，肺内皮屏障功能的调节，急性肺损伤，氧化应激中的线粒体功能和信号传导，以及气道上皮和血管内皮功能中离子通道的参与。我们的项目仍然是美国南部仅有的三个提供肺部研究博士前培训的项目之一，将由玛丽汤斯利博士和特洛伊史蒂文斯博士共同指导，与内部咨询委员会协商，并由杰出的外部顾问进行年度审查。培训计划的总体结构是基于NIH和其他国家科学领导小组对广泛的跨学科培训的高度重视。我们的博士前培训计划的基础设施是由基础医学博士的跨学科核心课程提供的。程序.博士前学员将由T32支持2-3年。这些学员致力于肺生物学轨道，从计划教师中确定一位导师，并完成信号，生物统计学/实验设计和肺生物学/病理生物学的严格教学高级课程。除了正式的学术课程外，博士前学员还将参加研讨会和正在进行的研究期刊俱乐部，以及由肺生物学中心组织的杰出职业生存技能培训。短期实习生进入一个长期组织良好的医学生暑期研究计划。这些学员将完成一个为期10周的研究项目，重点是肺生物学/病理生物学与该计划的教师之一。暑期培训包括一系列必要的研讨会。我们的培训计划受益于来自医学院五个系的25名资金充足，高度合作和国家认可的教师的研究和指导专业知识，所有这些都隶属于 肺部生物学中心我们的目标是提供一个充满活力的培训环境，为学员在学术，工业和/或政府生物医学研究场所的后续职业做好准备。

DESCRIPTION (provided by applicant): This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.