Sequencing and microbiome profiling core

项目总结 核心A 这个核心的目的是提供对转录本、甲基组、 外显体和微生物体。下一代测序仪已经改变了基因组研究，但 这些数据的生成和分析仍然是一个瓶颈。我们的核心将提供必要的排序和 数据分析服务，使该联盟的成员能够访问和解释这些数据。这个 PIS和这一核心的工作人员在基因组数据的生成和分析以及 熟悉相关项目的基本生物学知识。尽管其他测序核心 存在于加州大学洛杉矶分校，但它们都不能提供本文提出的所有服务。我们在这里提议的核心将是 使该联盟内的小组不仅能够从他们的样本中收集测序数据，而且 还可以获得经过处理和分析的数据，这些数据可以由研究人员直接解释，而不需要大量的 计算专业知识。这一功能应该使所有人都更容易获得基因组学研究 这个联盟的成员。

PROJECT SUMMARY Core A The purpose of this core is to provide sequencing and bioinformatic analyses of transcriptomes,methylomes, exomes and mircobiomes. Next-generation sequencers have transformed genomic research, yet the generation and analysis of this data remains a bottleneck. Our core will provide the essential sequencing and data analysis service to render this data accessible and interpretable to the members of this consortium. The PIs and staff of this core have extensive experience in the generation and analysis of genomic data, as well as familiarity with the underlying biology of the associated projects. Despite the fact that other sequencing cores exist at UCLA, none of these provide all the services proposed herein. The core we are proposing here will enable the groups within this consortium to be able to not only collect sequencing data from their samples, but also obtain processed and analyzed data that can be directly interpreted by researchers without extensive computational expertise. This functionality should render genomics research far more accessible to all members of this consortium.